Evidence map›Paper›PMID 39484398›Full record

ArticlebioRxiv : the preprint server for biology2025

Blood pressure variability compromises vascular function in middle-aged mice.

Perenkita J Mendiola, Philip O'Herron, Kun Xie, Michael W Brands, Weston Bush, Rachel E Patterson, Valeria Di Stefano, Jessica A Filosa

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Perenkita J MendiolaDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Philip O'HerronDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID 0000-0002-8137-9432
Kun XieDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Michael W BrandsDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Weston BushDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Rachel E PattersonDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Valeria Di StefanoDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.
Jessica A FilosaDepartment of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID 0000-0001-7536-2039

Funding

The impact of blood pressure variability on neurovascular function (Diversity Supplement)R01NS123644 · NINDS · AUGUSTA UNIVERSITY · PI JESSICA A FILOSA · 2023 to 2026
$2.1M
Clinically unscreened vasculo-glial-neuronal coupling is critical for physiological brain functionR01NS097818 · NINDS · AUGUSTA UNIVERSITY · PI FILOSA, JESSICA A · 2017 to 2021
$1.8M
The impact of blood pressure variability on neurovascular functionR56NS123644 · NINDS · AUGUSTA UNIVERSITY · PI FILOSA, JESSICA A · 2021 to 2021
$530k
NINDS NIH HHS R01 NS097818NINDS NIH HHS R01 NS123644NINDS NIH HHS R56 NS123644
6 · The paper itself

Abstract

Blood pressure variability (BPV) has emerged as a significant risk factor for cognitive decline and dementia, independent of alterations in average blood pressure (BP). However, the impact of large BP fluctuations on neurovascular function remains poorly understood. In this study, we developed a novel murine model of BPV in middle-aged mice using intermittent Angiotensin II infusions. Radio telemetry confirmed that 24-hr BP averages in BPV mice remained comparable to controls, demonstrating BPV in the absence of hypertension. Chronic (20-25 days) BPV resulted in a blunted bradycardic response and cognitive deficits. Two-photon imaging revealed heightened pressure-evoked constrictions (myogenic response) in parenchymal arterioles of BPV mice. While sensory stimulus-evoked dilations (neurovascular coupling) were amplified at higher BP levels in control mice, this pressure-dependent effect was abolished in BPV mice. Our findings indicate that chronic BP fluctuations impair vascular function within the neurovascular complex and contribute to cognitive decline, emphasizing BPV as a critical factor in brain health.

Identifiers

PMID39484398
PMCPMC11526967

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.