ArticlebioRxiv : the preprint server for biology2025
Fiber Microstructure Quantile (FMQ) Regression: A Novel Statistical Approach for Analyzing White Matter Bundles from Periphery to Core.
Zhou Lan, Yuqian Chen, Jarrett Rushmore, Leo Zekelman, Nikos Makris, Yogesh Rathi, Alexandra J Golby, Fan Zhang, Lauren J O'Donnell
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Zhou Lan
Yuqian Chen
Jarrett Rushmore
Leo Zekelman
Nikos Makris
Yogesh Rathi
Alexandra J Golby
Fan Zhang
Lauren J O'Donnell
Funding
TRD 3 - Enabling Technologies for Intraprocedural GuidanceP41EB028741 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI Oliver Jonas · 2021 to 2026
$10.7MNeural substrates of diffusion imaging in cognitively aging rhesus monkeysR01AG042512 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI KUBICKI, MAREK, MAKRIS, NIKOLAOS · 2013 to 2023
$6.5MMapping the superficial white matter connectome of the human brain using ultra high resolution multi-contrast diffusion MRIR01MH125860 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2021 to 2025
$4.1MHarmonizing multi-site diffusion MRI acquisitions for neuroscientific analysis across ages and brain disordersR01MH119222 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI O'DONNELL, LAUREN JEAN, RATHI, YOGESH · 2019 to 2023
$4.0MQuantitative Glioblastoma Margin and Infiltration Mapping with Advanced Diffusion-Relaxation MRIR01NS125781 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI ALEXANDRA J GOLBY, Carl-Fredrik Westin · 2022 to 2026
$3.6MUnraveling the Superficial White Matter of the Primate Brain: Tracer-Based Histology and dMRI Tractography ValidationR01NS125307 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NIKOLAOS MAKRIS, RICHARD Jarrett RUSHMORE · 2022 to 2026
$3.4MResearch Supplement: Naturalistic Neuroimaging for Presurgical Language MappingR01DC020965 · NIDCD · BRIGHAM AND WOMEN'S HOSPITAL · PI Einat Liebenthal, Yanmei Tie · 2023 to 2026
$2.7MMapping of the intrinsic and extrinsic cerebellar connectome at ultra high resolution with expert neuroanatomical curationR01MH132610 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI MAKRIS, NIKOLAOS, O'DONNELL, LAUREN JEAN · 2023 to 2025
$2.6MElucidating the Three-Dimensional Organization of the Human Cerebellar Cortex Using Histological and Ultra-High Resolution Structural MRI ApproachesR21NS136960 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MAKRIS, NIKOLAOS, RUSHMORE, RICHARD JARRETT · 2024 to 2025
$472kNIA NIH HHS R01 AG042512NIBIB NIH HHS P41 EB028741NIDCD NIH HHS R01 DC020965NIMH NIH HHS R01 MH119222NIMH NIH HHS R01 MH125860NIMH NIH HHS R01 MH132610NINDS NIH HHS R01 NS125307NINDS NIH HHS R01 NS125781NINDS NIH HHS R21 NS136960
6 · The paper itselfAbstract
The structural connections of the brain's white matter are critical for brain function. Diffusion MRI tractography enables the in-vivo reconstruction of white matter fiber bundles and the study of their relationship to covariates of interest, such as neurobehavioral or clinical factors. In this work, we introduce Fiber Microstructure Quantile (FMQ) Regression, a new statistical approach for studying the association between white matter fiber bundles and scalar factors (e.g., cognitive scores). Our approach analyzes tissue microstructure measures based on
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PMID39484397
PMCPMC11526951
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