Evidence map›Paper›PMID 39484259›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Exploratory Randomised Trial of Tranexamic Acid to Decrease Postoperative Delirium in Adults Undergoing Lumbar Fusion: A trial stopped early.

Bradley J Hindman, Catherine R Olinger, Royce W Woodroffe, Mario Zanaty, Carolina Deifelt Streese, Zeb R Zacharias, Jon C D Houtman, Linder H Wendt, Patrick P Ten Eyck, Debra J O'Connell-Moore and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Bradley J HindmanDepartment of Anesthesia, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Catherine R OlingerDepartment of Orthopedics and Rehabilitation, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Royce W WoodroffeDepartment of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Mario ZanatyDepartment of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Carolina Deifelt StreeseDepartment of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Zeb R ZachariasHuman Immunology Core Laboratory, University of Iowa, Iowa City, Iowa, USA.
Jon C D HoutmanHuman Immunology Core Laboratory, University of Iowa, Iowa City, Iowa, USA.
Linder H WendtInstitute for Clinical and Translational Science, University of Iowa, Iowa City, Iowa, 52242, USA.
Patrick P Ten EyckInstitute for Clinical and Translational Science, University of Iowa, Iowa City, Iowa, 52242, USA.
Debra J O'Connell-MooreInstitute for Clinical and Translational Science, University of Iowa, Iowa City, Iowa, 52242, USA.
Emanuel J RayDepartment of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Sarah J LeeDepartment of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Daniel F WaldschmidtInstitute for Clinical and Translational Science, University of Iowa, Iowa City, Iowa, 52242, USA.
Lauren G HavertapeInstitute for Clinical and Translational Science, University of Iowa, Iowa City, Iowa, 52242, USA.
Lanchi B NguyenInstitute for Clinical and Translational Science, University of Iowa, Iowa City, Iowa, 52242, USA.
Pei-Fu ChenDepartment of Anesthesiology, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Matthew I BanksDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Robert D SandersCentral Clinical School and National Health and Medical Research Council (NHMRC) Clinical Trials Centre, University of Sydney, Sydney, Australia.
Matthew A HowardDepartment of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Mark E Burkard · 2000 to 2026
$70.0M
University of Iowa Institute for Clinical and Translational ScienceUM1TR004403 · NCATS · UNIVERSITY OF IOWA · PI Marlan R Hansen, Patricia Winokur · 2023 to 2026
$16.1M
NCATS NIH HHS UM1 TR004403NCI NIH HHS P30 CA086862
6 · The paper itself

Abstract

Background: Postoperative delirium may be mediated by perioperative systemic- and neuro-inflammation. By inhibiting the pro-inflammatory actions of plasmin, tranexamic acid (TXA) may decrease postoperative delirium. To explore this hypothesis, we modified an ongoing randomised trial of TXA, adding measures of postoperative delirium, cognitive function, systemic cytokines, and astrocyte activation. Methods: Adults undergoing elective posterior lumbar fusion randomly received intraoperative intravenous TXA (n=43: 10 mg kg Results: Delirium incidence in the TXA group (7/32=22%) was not significantly less than in the Placebo group (11/33=33%); Conclusions: A potential 33% relative decrease in postoperative delirium incidence justifies an adequately powered clinical trial to determine if intraoperative TXA decreases delirium in adults undergoing lumbar fusion.

Indexed as

Clinical trialCytokinesDeliriumS100BSpinal fusionTranexamic acid

Identifiers

PMID39484259
PMCPMC11527054

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.