Evidence map›Paper›PMID 39484251›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Plasma acellular transcriptome contains Parkinson's disease signatures that can inform clinical diagnosis.

Aleksandra Beric, Alejandro Cisterna-García, Charissa Martin, Ravindra Kumar, Isabel Alfradique-Dunham, Kevin Boyer, Ibrahim Olabayode Saliu, Shinnosuke Yamada, Jessie Sanford, Daniel Western and 8 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Aleksandra BericDepartment of Psychiatry, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-9351-585X
Alejandro Cisterna-GarcíaDepartamento de Ingeniería de la Información y las Comunicaciones; Universidad de Murcia, Murcia, Spain.ORCID 0000-0002-9927-7178
Charissa MartinDepartment of Psychiatry, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-8229-2980
Ravindra KumarDepartment of Psychiatry, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-0121-8402
Isabel Alfradique-DunhamDepartment of Neurology, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-7723-2956
Kevin BoyerDepartment of Genetics, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.
Ibrahim Olabayode SaliuDepartment of Genetics, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6182-5992
Shinnosuke YamadaDepartment of Genetics, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.
Jessie SanfordDepartment of Psychiatry, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-5992-3027
Daniel WesternDepartment of Psychiatry, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-3725-9553
Menghan LiuDepartment of Psychiatry, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0008-9902-5983
Ignacio AlvarezDepartment of Pathology, Germans Trias I Pujol Research Institute, Badalona, Spain.ORCID 0000-0002-8537-3935
Joel S PerlmutterNeurology, Radiology, Neuroscience, Physical Therapy, Occupational Therapy, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.
Scott A NorrisDepartments of Neurology and Radiology, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.
Pau PastorDepartment of Neurology, Hospital Germans Trias i Pujol, and Genomics and Transcriptomics of Synucleinopathies (GTS), The Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain.ORCID 0000-0002-7493-8777
Guoyan ZhaoDepartment of Genetics, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-5615-6774
Juan BotiaDepartamento de Ingeniería de la Información y las Comunicaciones; Universidad de Murcia, Murcia, Spain.ORCID 0000-0002-6992-598X
Laura IbanezDepartment of Psychiatry, Washington University in Saint Louis School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-2381-7059

Funding

Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Susan Lynn Stark · 2020 to 2026
$28.7M
INVESTIGATIONS OF DEMENTIA IN PARKINSON DISEASER01NS075321 · NINDS · WASHINGTON UNIVERSITY · PI CAMPBELL, MEGHAN C, PERLMUTTER, JOEL SYNES · 2011 to 2021
$8.2M
Neuroimaging of PDE10AR01NS103957 · NINDS · WASHINGTON UNIVERSITY · PI PERLMUTTER, JOEL SYNES, TU, ZHUDE · 2017 to 2021
$3.1M
Plasma Cell-Free RNA as Non-invasive Biomarker for NeurodegenerationR00AG062723 · NIA · WASHINGTON UNIVERSITY · PI IBANEZ, LAURA · 2022 to 2024
$729k
Plasma Cell-Free RNA as Non-invasive Biomarker for NeurodegenerationK99AG062723 · NIA · WASHINGTON UNIVERSITY · PI IBANEZ, LAURA · 2020 to 2021
$250k
NIA NIH HHS K99 AG062723NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS R00 AG062723NINDS NIH HHS R01 NS075321NINDS NIH HHS R01 NS103957
6 · The paper itself

Abstract

We aimed to identify plasma cell-free transcripts (cfRNA) associated with Parkinson's disease (PD) that also have a high predictive value to differentiate PD from healthy controls. Leveraging two independent populations from two different movement disorder centers we identified 2,188 differentially expressed cfRNAs after meta-analysis. The identified transcripts were enriched in PD relevant pathways, such as PD (p=9.26×10

Identifiers

PMID39484251
PMCPMC11527085

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.