Evidence map›Paper›PMID 39484246›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Examining the causal genetic effects of substance use on aging.

Jared V Balbona, Paul Jeffries, Aaron J Gorelik, Elliot C Nelson, Ryan Bogdan, Arpana Agrawal, Emma C Johnson

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jared V BalbonaWashington University School of Medicine in St. Louis, Dept. of Psychiatry.ORCID 0000-0003-4466-248X
Paul JeffriesWashington University School of Medicine in St. Louis, Dept. of Psychiatry.
Aaron J GorelikWashington University in St. Louis, Department of Psychological & Brain Sciences.ORCID 0000-0002-2589-1220
Elliot C NelsonWashington University School of Medicine in St. Louis, Dept. of Psychiatry.
Ryan BogdanWashington University in St. Louis, Department of Psychological & Brain Sciences.
Arpana AgrawalWashington University School of Medicine in St. Louis, Dept. of Psychiatry.
Emma C JohnsonWashington University School of Medicine in St. Louis, Dept. of Psychiatry.

Funding

BIOMEDICAL RESEARCH TRAINING IN DRUG ABUSET32DA007261 · NIDA · WASHINGTON UNIVERSITY · PI ARPANA AGRAWAL, Jose A Moron-Concepcion · 1991 to 2026
$8.8M
7/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01DA054869 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2021 to 2025
$3.3M
Identifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics dataK01DA051759 · NIDA · WASHINGTON UNIVERSITY · PI JOHNSON, EMMA COVEY · 2021 to 2025
$816k
NIDA NIH HHS K01 DA051759NIDA NIH HHS R01 DA054869NIDA NIH HHS T32 DA007261
6 · The paper itself

Abstract

Substance use shortens lifespan, impedes health, and accelerates the biological aging process. We found widespread genetic correlations between alcohol, tobacco, cannabis, and opioid use and use disorders with indices of aging across the lifespan. There was evidence of tobacco and alcohol use and use disorders causally impacting physical, cognitive, and biological aging, with the effects of alcohol being more dependent on quantity of consumption; evidence of reverse causality was scant.

Identifiers

PMID39484246
PMCPMC11527072

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.