Evidence map›Paper›PMID 39483921›Full record

ArticleResearch square2024

Cell Populations in Human Breast Cancers are Molecularly and Biologically Distinct with Age.

Adrienne Parsons, Esther Sauras Colon, Milos Spasic, Busem Binboga Kurt, Alexander Swarbrick, Rachel A Freedman, Elizabeth A Mittendorf, Peter van Galen, Sandra S McAllister

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Adrienne ParsonsDivision of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Esther Sauras ColonDivision of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Milos SpasicDivision of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Busem Binboga KurtDivision of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.
Alexander SwarbrickCancer Ecosystems Program, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.ORCID 0000-0002-3051-5676
Rachel A FreedmanDepartment of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Elizabeth A MittendorfDivision of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.
Peter van GalenDivision of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-0735-1570
Sandra S McAllisterDivision of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0002-5111-5903

Funding

RESEARCH TRAINING-MEDICAL INFORMATICS 90T15LM007092 · NLM · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Nils Gehlenborg · 1992 to 2026
$32.8M
Understanding the impact of chemotherapy on breast cancer metastasis and immune function in the liverR01CA279959 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Sandra S McAllister · 2023 to 2026
$2.0M
Clonal analysis of cancer by mitochondrial DNA barcodingR33CA278393 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI SANKARAN, VIJAY GANESH, VAN GALEN, PETER · 2023 to 2025
$1.3M
NCI NIH HHS R01 CA279959NCI NIH HHS R33 CA278393NLM NIH HHS T15 LM007092
6 · The paper itself

Abstract

Aging is associated with increased breast cancer risk and outcomes are worse for the oldest and youngest patients, regardless of subtype. It is not known how cells in the breast tumor microenvironment are impacted by age and how they might contribute to age-related disease pathology. Here, we discover age-associated differences in cell states and interactions in human estrogen receptor-positive (ER+) and triple-negative breast cancers (TNBC) using new computational analyses of existing single-cell gene expression data. Age-specific program enrichment (ASPEN) analysis reveals age-related changes, including increased tumor cell epithelial-mesenchymal transition, cancer-associated fibroblast inflammatory responses, and T cell stress responses and apoptosis in TNBC. ER+ breast cancer is dominated by increased cancer cell estrogen receptor 1 (

Identifiers

PMID39483921
PMCPMC11527348

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.