ArticleCureus2024
Clomiphene-Induced Portal Vein Thrombosis and Superior Mesenteric Venous Thrombosis.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Tricky acute mesenteric ischemia: what can we do?Gastroenterology report · 2025Review
- Clomiphene-induced myocardial infarction in a young male: A case report of a rare cardiovascular complication.Science progressArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clomiphene citrate is a selective estrogen receptor modulator commonly used off-label for male infertility despite being approved only for female infertility. Clomiphene is generally safe, and serious adverse effects such as venous thrombosis are rarely reported. This report presents the case of a 32-year-old man who developed portal vein thrombosis (PVT) and superior mesenteric venous thrombosis (SMVT) following three months of clomiphene therapy for infertility. The patient presented with severe abdominal pain and was found to have acute thrombosis on CT imaging. No other underlying hypercoagulable condition was present, and clomiphene was identified as a possible provoking factor for the thrombosis. The patient was successfully treated with anticoagulation therapy and was discharged on dabigatran for six months, with follow-up imaging planned. This is the first reported case linking clomiphene use to PVT and SMVT. Further studies are necessary to better understand the degree of risk and mechanisms underlying clomiphene-induced thrombosis.
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Registered trials
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