Evidence map›Paper›PMID 39483216›Full record

ArticleJACS Au2024

A Self-Immobilizing Photosensitizer with Long-Term Retention for Hypoxia Imaging and Enhanced Photodynamic Therapy.

Zifan Zhu, Yun Feng, Qiufen Tian, Jiawen Li, Chencong Liu, Yuchi Cheng, Sanjun Zhang, Yijing Dang, Jing Gao, Yi Lai and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zifan ZhuSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
Yun FengSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
Qiufen TianSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
Jiawen LiSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
Chencong LiuSchool of Pharmacy, China Pharmaceutical University, Nanjing 211198, China.
Yuchi ChengState Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200241, China.
Sanjun ZhangState Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200241, China.ORCID https://orcid.org/0000-0002-7377-2429
Yijing DangSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
Jing GaoState Key Laboratory of Chemical Biology & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Yi LaiState Key Laboratory of Chemical Biology & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Fan ZhangDepartment of Chemistry, Fudan University, Shanghai 200433, China.ORCID https://orcid.org/0000-0001-7886-6144
Haijun YuState Key Laboratory of Chemical Biology & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.ORCID https://orcid.org/0000-0002-3398-0880
Wen ZhangSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.ORCID https://orcid.org/0000-0001-7918-4065
Zhiai XuSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.ORCID https://orcid.org/0000-0002-4391-2507

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The precise theranostic strategy of fluorescence imaging-guided photodynamic therapy (PDT) can effectively mitigate the adverse effect of photosensitizers in normal cells and tissues. However, low tumor enrichment and high diffusivity of photosensitizers significantly compromise the imaging accuracy and PDT effect. In this study, we have developed a nitroreductase (NTR)-activated and self-immobilizing photosensitizer CyNT-F, which showed enhanced enrichment in tumor tissues and facilitated precise and sustained imaging as well as PDT for hypoxia tumors. mPEG-

Identifiers

PMID39483216
PMCPMC11522922

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.