ArticleAnimal bioscience2025
Transcriptome analysis revealed the mechanism of skeletal muscle growth and development in different hybrid sheep.
Article in Animal bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Effects of Aging on Muscle Development Based on Transcriptome Sequencing in Dahen Broilers.Animals : an open access journal from MDPI · 2026Article
- ANKRD9 negatively regulates chicken myogenesis through ubiquitin-mediated regulation of IMPDH2.Poultry science · 2026Article
- Comparative Analysis of Meat Quality Characteristics of theAnimals : an open access journal from MDPI · 2026Article
- Screening of Differentially Expressed Genes Related to Growth, Development and Meat Quality Traits of Huanghuai Sheep Based on RNA-Seq Technology.Animals : an open access journal from MDPI · 2025Article
- Article
- Potential candidate genes influencing meat production phenotypic traits in sheep: a review.Frontiers in veterinary science · 2025Review
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Authors and funding
7 authors.
Funding
Abstract
objectiveThis study aimed to analyze the molecular mechanism of heterosis in East Friesian sheep×Hu sheep (EH) hybrid sheep and Suffolk×EH (SHE) hybrid sheep (Ovis aries).
methodsIn this research, the growth performance data of Hu sheep (H), EH and SHE from birth to 8 months of age were analyzed. Three 8-month-old sheep of each of the three strains (9 sheep in total) were chosen and their longissimus dorsi muscles were collected for transcriptome sequencing. We verified the expression of seven differentially expressed genes (DEGs) by real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR).
resultsThe results showed: (1) body weight and chest circumference of EH were significantly greater than H (p<0.05), except at 4 months of age. Body weight and chest circumference of SHE was significantly higher than EH (p<0.05), except at 6 months of age. (2) 310 DEGs were screened in the EH and H, gene ontology and Kyoto encyclopedia of genes and genomes showed DEGs were mainly concentrate on the categories of actin cytoskeleton, calcium binding, cGMP-PKG and mitogen-activated protein kinase (MAPK) signaling pathway, which correlating the development of skeletal muscle and energy metabolism. 329 DEGs were screened in the SHE and EH. DEGs were mainly enriched in extracellular matrix-receptor interactions and cell adhesion molecules. (3) Protein-protein interaction screening yielded five (MYL2, TNNI1, TNNI3, MYH11, TNNC1) and three (SOX10, COL2A1, MPZ) pivotal DEGs regulating muscle development in EH and SHE. (4) RT-qPCR test results were consistent with transcriptome sequencing.
conclusionThis study provides candidate genes for improving sheep growth traits. It provides a theoretical basis for analyzing the mechanism of muscle development in crossbred sheep.
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