Evidence map›Paper›PMID 39482857›Full record

ArticleAlcohol, clinical & experimental research2024

Impact of phosphatidylethanol in the surveillance for alcohol use in post-liver transplant population: A retrospective study.

Sergio A De La Torre, Brittney Ibrahim, Katherine Meneses, Sammy Saab, Akshay Shetty

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Article in Alcohol, clinical & experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Sergio A De La TorreDepartment of Medicine, University of California at Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-5213-2780
Brittney IbrahimDepartment of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Katherine MenesesDepartment of Surgery, University of California at Los Angeles, Los Angeles, California, USA.
Sammy SaabDepartment of Medicine, University of California at Los Angeles, Los Angeles, California, USA.
Akshay ShettyDepartment of Medicine, University of California at Los Angeles, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-9261-1639

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlcohol-related liver disease (ALD) is the leading indication for liver transplantation in the United States. The aim of this study was to describe the impact of phosphatidylethanol (PEth) in the surveillance for alcohol use after liver transplantation.

methodsWe conducted a single-center retrospective study to assess the impact of phosphatidylethanol (PEth) for the surveillance of alcohol use and its correlation to health outcomes. We compared orthotopic liver transplant (OLT) recipients for ALD transplanted between 2016 and 2018, before the introduction of PEth, to those transplanted between 2019 and 2022, after the introduction of PEth. Alcohol relapse versus nonrelapse cohorts were also compared. Follow-up time for all cohorts was limited to 3 years post-OLT. Continuous variables were analyzed with an independent t-test and categorical variables with Fischer's exact test and chi-square test. The Kaplan-Meier method and log-rank test were used to assess alcohol-free survival.

resultsWe reviewed 263 patients who were transplanted for ALD; 46 (17.5%) patients were noted to have at least one episode of alcohol relapse after their transplant. Patients with alcohol relapse had more frequent episodes of elevated liver enzymes compared with nonrelapsed patients (4.35 episodes vs. 2.46 episodes respectively, p < 0.001). The number of hospitalizations was also noted to be elevated among relapsed versus nonrelapsed patients; however, this was not statistically significant (2.85 vs. 2.50 respectively, p = 0.307). When comparing relapse rates before and after the introduction of PEth, relapses were notably detected more frequently after the introduction of PEth (17% vs. 7%, p = 0.012). No difference was noted in rates of mortality between patients who did or did not relapse.

conclusionsOverall, PEth is an effective surveillance tool in the postliver transplant population to monitor for alcohol relapse. Early detection of relapse can lead to opportunities for early intervention to avoid alcohol-related complications.

Indexed as

alcohol relapsealcohol‐related liver diseaseliver transplantPEthphosphatidylethanol

Identifiers

PMID39482857
PMCPMC11629445

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