Evidence map›Paper›PMID 39482802›Full record

ArticleJournal of cosmetic dermatology2025

Comparison and Assessment of Anti-Inflammatory and Antioxidant Capacity Between EGCG and Phosphatidylcholine-Encapsulated EGCG.

Minjia Yuan, Lili Hu, Cuicui Zhu, Qi Li, Hang Tie, Haihua Ruan, Tao Wu, Hongyang Zhang, Liang Xu

Abstract readComparative Study
In one paragraph

Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Minjia YuanSchool of Pharmacy, Tianjin Medical University, Tianjin, People's Republic of China.
Lili HuSchool of Pharmacy, Tianjin Medical University, Tianjin, People's Republic of China.
Cuicui ZhuShanghai Qiran Biotechnology Co. Ltd., Shanghai, People's Republic of China.
Qi LiShanghai Qiran Biotechnology Co. Ltd., Shanghai, People's Republic of China.
Hang TieSchool of Pharmacy, Tianjin Medical University, Tianjin, People's Republic of China.
Haihua RuanTianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Tao WuTianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Hongyang ZhangTianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China.
Liang XuSchool of Pharmacy, Tianjin Medical University, Tianjin, People's Republic of China.

Funding

Fundamental research project of Chinese Academy of Inspection and Quarantine 2022JK26
6 · The paper itself

Abstract

aimTo compare and evaluate the differences between EGCG and phosphatidylcholine-encapsulated EGCG in terms of their anti-inflammatory and antioxidant capacities.

methodsIn this study, transdermal absorption experiments were conducted to compare the absorption capacity of EGCG and phosphatidylcholine-encapsulated EGCG. Subsequently, the disparity in anti-inflammatory and antioxidant efficacy between EGCG and phosphatidylcholine-encapsulated EGCG were evaluated through cytotoxicity experiments, as well as the determination of cellular inflammatory factors and the measurement of ROS content under different treatment conditions.

resultsThe concentration of EGCG, encapsulated in phosphatidylcholine, in porcine skin is 40.76 ± 1.29 μg/cm

conclusionThe percutaneous absorption and anti-inflammatory impact of EGCG encapsulated within phosphatidylcholine were substantially enhanced when compared to EGCG by itself. Additionally, both formulations exhibited enhanced ROS scavenging capacities, albeit the variance between them was not pronounced. These insights furnish a vital theoretical underpinning for the utilization of phosphatidylcholine-encapsulated EGCG in cosmetic applications, specifically for fostering products with anti-inflammatory and antioxidant benefits.

Indexed as

Anti-Inflammatory AgentsAntioxidantsCatechinPhosphatidylcholinesAdministration, CutaneousAnimalsDinoprostoneHumansReactive Oxygen SpeciesSkinSkin AbsorptionSwineTumor Necrosis Factor-alphaAnti-Inflammatory AgentsAntioxidantsCatechinDinoprostoneepigallocatechin gallatePhosphatidylcholinesReactive Oxygen SpeciesTumor Necrosis Factor-alphaantioxidantcosmetic raw materialsEGCGphosphatidylcholine‐encapsulated EGCGproinflammatory factors

Identifiers

PMID39482802
PMCPMC11743248

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.