Evidence map›Paper›PMID 39482727›Full record

ArticleTropical diseases, travel medicine and vaccines2024

The role of antibody-dependent enhancement in dengue vaccination.

D G Aynekulu Mersha, I van der Sterren, L P M van Leeuwen, T Langerak, M S Hakim, B Martina, S F L van Lelyveld, E C M van Gorp

Abstract read
In one paragraph

Article in Tropical diseases, travel medicine and vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Article
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  6. Article
  7. Article
  8. Review
  9. Article
  10. Global Genomic Surveillance: On-The-Ground Responses.Current topics in microbiology and immunology · 2026
    Review
  11. Article
  12. Review
  13. Harnessing Nanocarriers to Advance Vaccine Development.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

D G Aynekulu MershaDepartment of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 40, PO Box Ee-1722, Rotterdam, 3015 GD, the Netherlands. d.aynekulumersha@erasmusmc.nl.
I van der SterrenDepartment of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 40, PO Box Ee-1722, Rotterdam, 3015 GD, the Netherlands.
L P M van LeeuwenDepartment of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 40, PO Box Ee-1722, Rotterdam, 3015 GD, the Netherlands.
T LangerakDepartment of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 40, PO Box Ee-1722, Rotterdam, 3015 GD, the Netherlands.
M S HakimPostgraduate School of Molecular Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
B MartinaArtemis Bioservices and Athenavax B.V, Delft, the Netherlands.
S F L van LelyveldDepartment of internal medicine, Spaarne Gasthuis, Haarlem/Hoofddorp, the Netherlands.
E C M van GorpDepartment of Viroscience, Erasmus Medical Center, Dr. Molewaterplein 40, PO Box Ee-1722, Rotterdam, 3015 GD, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue is the most rapidly spreading vector-borne disease worldwide, with over half the global population at risk for an infection. Antibody-dependent enhancement (ADE) is associated with increased disease severity and may also be attributable to the deterioration of disease in vaccinated people. Two dengue vaccines are approved momentarily, with more in development. The increasing use of vaccines against dengue, combined with the development of more, makes a thorough understanding of the processes behind ADE more important than ever. Above that, due to the lack of treatment options, this method of prevention is of great importance. This review aims to explore the impact of ADE in dengue vaccinations, with the goal of enhancing potential vaccination strategies in the fight against dengue.

Identifiers

PMID39482727
PMCPMC11529159

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.