Evidence map›Paper›PMID 39482634›Full record

ArticleBMC public health2024

Interpreting epidemiologic distribution of total and specific IgE levels for food allergy in Southern China from 2004 to 2023: understanding the mechanisms and focusing on prevention.

Mingtao Liu, Li Liu, Weitian Qi, Xianhui Zheng, Jiaxi Chen, Jiani Yao, Yufeng Li, Jinhong Lin, Xiangyu Li, Xiangyi Hu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mingtao Liu *Department of Clinical Laboratory of the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, 510120, China.
Li Liu *KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 511495, China.
Weitian Qi *Second Clinical Medical School, Southern Medical University, Guangzhou, 510515, China.
Xianhui Zheng *Department of Clinical Laboratory of the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, 510120, China.
Jiaxi Chen *KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 511495, China.
Jiani YaoKingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 511495, China.
Yufeng LiSecond Clinical Medical School, Southern Medical University, Guangzhou, 510515, China.
Jinhong LinKingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 511495, China.
Xiangyu LiKingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 511495, China.
Xiangyi HuCollege of Plant Protection, China Agricultural University, Beijing, 100091, China.
Zhangkai J ChengDepartment of Clinical Laboratory of the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, 510120, China. jasontable@gmail.com.
Huimin HuangDepartment of Clinical Laboratory of the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, 510120, China. huanghuimin311@126.com.
Baoqing SunDepartment of Clinical Laboratory of the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, 510120, China. sunbaoqing@vip.163.com.

Funding

Guangdong Key Areas R&D Program 2022B0202030002Guangdong Zhong Nanshan Medical Foundation ZNSXS-20220011Natural Science Foundation of Guangdong Province 2021B1515230008
6 · The paper itself

Abstract

backgroundThe burgeoning prevalence of food allergy-related diseases is closely associated with geographical allergen distribution and societal lifestyle paradigms. This study aims to shed light on the distribution patterns of specific IgE (sIgE) and total IgE (tIgE) reactivity to common food allergens in the Southern Chinese populace.

methodsEmploying an analytical technique spanning two decades, we conducted specific IgE and total IgE on serum samples harvested from patients with food allergy-related pathologies at First Affiliated Hospital of Guangzhou Medical University from 2004 to 2023. This comprehensive examination of eight prototypical food allergens: egg white, milk, wheat, sesame, peanut, soybean, shrimp, and crab.

resultsOur analysis showed a 100% positivity rate for sIgE and an 86.54% positivity rate for tIgE. Milk had the highest positive response rate, followed by egg white and shrimp. Age-stratified data indicated that milk sensitization peaked in children aged 2 years or younger, while egg white sensitization peaked between 3 and 5 years of age. Sensitization rates for the remaining six allergens increased with age. Additionally, co-sensitization was observed between milk, egg white, crab, and shrimp with other allergens.

conclusionIn common allergens of Southern China, egg white, milk, and shrimp ascend as the dominant subjects, underlining their imperative role in food allergy pathogenesis. This landscape-wide allergenic profiling, segregated across age clusters and enhanced by co-sensitization data, augments our power for early diagnosis and strategic intervention in food allergy diseases.

Indexed as

AllergensFood HypersensitivityImmunoglobulin EAdolescentAdultChildChild, PreschoolChinaFemaleHumansInfantMaleMiddle AgedPrevalenceYoung AdultAllergensImmunoglobulin EDistribution patternFood allergensSouthern ChinaSpecific IgETotal IgE

Identifiers

PMID39482634
PMCPMC11529331

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.