Evidence map›Paper›PMID 39482605›Full record

ArticleBMC nephrology2024

Better health-related quality of life is associated with prolonged survival and reduced hospitalization risk among dialysis-dependent chronic kidney disease patients: a historical cohort study.

Abraham Rincon Bello, Jasmine Ion Titapiccolo, Isabel Berdud Godoy, Diana J C Samaniego, Sofia Ortego Perez, Alicia Sobrino Perez, Kateryna Shkolenko, Stefano Stuard, Luca Neri, Maria Eva Baró Salvador

Abstract read
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Article in BMC nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abraham Rincon BelloFresenius Medical Care, Nephrocare, Madrid, Spain.
Jasmine Ion TitapiccoloData Science Division - Clinical Advanced Analytics, Global Medical Office - Fresenius Medical Care, Vaiano Cremasco, Italy.
Isabel Berdud GodoyFresenius Medical Care, Nephrocare, Madrid, Spain.
Diana J C SamaniegoFresenius Medical Care, Nephrocare, Madrid, Spain.
Sofia Ortego PerezFresenius Medical Care, Nephrocare, Madrid, Spain.
Alicia Sobrino PerezFresenius Medical Care, Nephrocare, Madrid, Spain.
Kateryna ShkolenkoFresenius Medical Care, Nephrocare, Madrid, Spain.
Stefano Stuard *EMEA Chief Clinical Officer, Global Medical Office - Clinical Affairs, CoE Clinical & Therapeutic Governance - Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany.
Luca Neri *Data Science Division - Clinical Advanced Analytics, Global Medical Office - Fresenius Medical Care, Vaiano Cremasco, Italy. luca.neri@fmc-ag.com.
Maria Eva Baró SalvadorFresenius Medical Care, Nephrocare, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RATIONALE &

objectiveEnd-stage kidney disease (ESKD) negatively affects patients' physical, emotional, and social functioning. Furthermore, adjustment to dialysis require substantial lifestyle changes that may further impact on patients physical and emotional well-being. However, the relationship between Health-Related Quality of life impairment with future adverse outcomes in dialysis is not well characterized. Our study aims to investigate the relationship between Health-Related Quality of Life (HRQoL) and patients' survival and hospitalization rates within a large European dialysis network.

methodsA historical cohort study was conducted to evaluate association of HRQoL with hospitalization and mortality rates over a 12-month follow-up period. Patients responded to a self-administered survey as part of a Continuous Quality Improvement Program implemented in clinics affiliated with the Spanish FMC-Nephrocare organization. Health-Related Quality of Life (HRQoL) was measured with the KDQOL-36. Potential confounders included socio-demographic characteristics, comorbidities, biochemical parameters, dialysis treatment. We used Cox's Proportional Hazard regression to assess the hazard of death and Logistic Regression to assess the likelihood of hospital admissions during 12-month follow-up period.

resultsA total of 2280 (51.5%) completed the self-administrated survey, and 1838 patients met the inclusion/exclusion criteria of the study. Higher HRQoL scores were associated with significantly lower mortality and hospitalization risk. Risk estimates were robust to adjustment for potential confounders.

conclusionsSeveral dimensions of HRQoL are associated with patient-centered outcomes (i.e., mortality and hospitalizations at 1 year). Patient-Reported Outcomes contribute unique pieces of information characterizing patients' health. Residual confounding cannot be fully ruled out; moreover, the high attrition rate could result in selection bias, which may limit the generalizability of the findings to a broader population.

Indexed as

HospitalizationKidney Failure, ChronicQuality of LifeRenal DialysisAgedCohort StudiesFemaleHumansMaleMiddle AgedRenal Insufficiency, ChronicSurvival RateDialysisEnd Stage Kidney DiseaseHealth-Related Quality of LifeHospitalizationMortality

Identifiers

PMID39482605
PMCPMC11526659

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.