ArticleCell and tissue research1986
Multigranular exocytosis induced by phospholipase A2-activators, melittin and mastoparan, in rat anterior pituitary cells.
Article in Cell and tissue research, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 60 citations in OpenAlex.
- Bioactive Peptides and Proteins from Wasp Venoms.Biomolecules · 2022Review
- Differential Properties of Venom Peptides and Proteins in Solitary vs. Social Hunting Wasps.Toxins · 2016Review
- The neurotoxicological effects of mastoparan Polybia-MPII at the murine neuromuscular junction: an ultrastructural and immunocytochemical study.Histochemistry and cell biology · 2009Article
- Ca(2+)-independent fusion of synaptic vesicles with phospholipase A2-treated presynaptic membranes in vitro.The Biochemical journal · 1996Article
- Effects of mastoparan upon the late stages of the ACTH secretory pathway of AtT-20 cells.British journal of pharmacology · 1995Article
- Ca(2+)-independent fusion of secretory granules with phospholipase A2-treated plasma membranes in vitro.The Biochemical journal · 1995Article
- Coated vesicles are implicated in the post-fusion retrieval of the membrane of rat atrial secretory granules.Cell and tissue research · 1992Article
- Insulin releasing effects of mastoparan and amphiphilic substance P receptor antagonists on RINm5F insulinoma cells.Molecular and cellular biochemistry · 1992Article
- Mastoparan promotes exocytosis and increases intracellular cyclic AMP in human platelets. Evidence for the existence of a Ge-like mechanism of secretion.The Biochemical journal · 1992Article
- Characterization of a mastoparan-stimulated nucleotidase from bovine brain.The Biochemical journal · 1991Article
- Phospholipase A2 and mediation of the activation of short-circuit current in the rat colonic mucosa.Naunyn-Schmiedeberg's archives of pharmacology · 1991Article
- Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulation.The Journal of cell biology · 1991Article
- Ultrastructural visualization of exocytosis in the pig pineal gland.Cell and tissue research · 1991Article
- Compound versus multigranular exocytosis in peritoneal mast cells.The Journal of general physiology · 1990Article
- Neomycin inhibits mastoparan-induced lactate dehydrogenase release, ethidium bromide accumulation, and intracellular fluorescein depletion in MDCK cells.Cell biology and toxicology · 1990Article
- Morphofunctional study of mammotropic cells following intraventricular administration of met-enkephalin.Anatomy and embryology · 1989Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effects of phospholipase A2-activators, melittin and mastoparan, on rat anterior pituitary cells were studied by use of the electron microscope. Rat anterior pituitaries were incubated in HEPES buffer containing 20 micrograms/ml of melittin or the same dose of mastoparan for 5 min, 10 min and 20 min. Features indicating discharge of granule contents by exocytosis were increased with time, and the simultaneous extrusion of a number of secretory granules, named "multigranular exocytosis", was often recognized in addition to single-granule exocytosis at 10 min and 20 min. Most membrane pits, where the multigranular exocytosis as well as the single-granule exocytosis occurred, were coated. Moreover, a large number of vesicles coated or non-coated were distributed near the trans side of the Golgi apparatus of melittin-treated or mastoparan-treated cells after 20 min. These vesicles might be related to membrane internalized from the excess surface membrane derived from the limiting membrane of exocytosed granules. These observations indicate that phospholipase A2-activators induce hormone release involving membrane fusion between limiting membranes of secretory granules, and between granule-limiting membrane and plasma membrane in rat anterior pituitary cells.
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