ArticleNature communications2024
Intersecting social and environmental determinants of multidrug-resistant urinary tract infections in East Africa beyond antibiotic use.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A Review of R Packages for Bayesian Model-based Clustering of High-dimensional Multivariate Environmental Exposures.Current environmental health reports · 2026Review
- Antimicrobial stewardship from a One Health perspective.Nature reviews. Microbiology · 2026Review
- Determinants of multidrug-resistant urinary tract infections: A retrospective cross-sectional study from a tertiary care hospital in southern Bangladesh.PLOS global public health · 2026Article
- Determinants of Multidrug Resistance Among Gram-Positive Uropathogens in Central Portugal: A 5-Year Retrospective Study.International journal of microbiology · 2026Article
- Profile of Biofilm Formation and Antimicrobial Susceptibility Patterns ofInfection and drug resistance · 2026Article
- Article
- Unraveling behavioral and sociocultural factors that shape antimicrobial use among patients and general public, Addis Ababa, Ethiopia, a qualitative study.Journal of pharmaceutical health care and sciences · 2025Article
- SatHealth: A Multimodal Public Health Dataset with Satellite-based Environmental Factors.KDD : proceedings. International Conference on Knowledge Discovery & Data Mining · 2025Article
- Modelling Interventions to Combat Antibacterial Resistance in East Africa Using Causal Bayesian Networks.Research square · 2025Article
- Associations between extreme weather events, resource insecurities, and HIV vulnerabilities with self-reported urinary tract infection symptoms among adolescent girls and young women in Kenya.The journal of climate change and healthArticle
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Authors and funding
28 authors.
Funding
Abstract
The global health crisis of antibacterial resistance (ABR) poses a particular threat in low-resource settings like East Africa. Interventions for ABR typically target antibiotic use, overlooking the wider set of factors which drive vulnerability and behaviours. In this cross-sectional study, we investigated the joint contribution of behavioural, environmental, socioeconomic, and demographic factors associated with higher risk of multi-drug resistant urinary tract infections (MDR UTIs) in Kenya, Tanzania, and Uganda. We sampled outpatients with UTI symptoms in healthcare facilities and linked their microbiology data with patient, household and community level data. Using bivariate statistics and Bayesian profile regression on a sample of 1610 individuals, we show that individuals with higher risk of MDR UTIs were more likely to have compound and interrelated social and environmental disadvantages: they were on average older, with lower education, had more chronic illness, lived in resource-deprived households, more likely to have contact with animals, and human or animal waste. This suggests that interventions to tackle ABR need to take account of intersectional socio-environmental disadvantage as a priority.
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