Evidence map›Paper›PMID 39482294›Full record

ReviewNature communications2024

Why experimental variation in neuroimaging should be embraced.

Gregory Kiar, Jeanette A Mumford, Ting Xu, Joshua T Vogelstein, Tristan Glatard, Michael P Milham

Abstract readReview
In one paragraph

Review in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gregory KiarCenter for Data Analytics, Innovation, and Rigor, Child Mind Institute, New York, NY, USA. gregory.kiar@childmind.org.ORCID 0000-0001-8915-496X
Jeanette A MumfordDepartment of Psychology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0926-3531
Ting XuCenter for Data Analytics, Innovation, and Rigor, Child Mind Institute, New York, NY, USA.ORCID 0000-0002-0065-3832
Joshua T VogelsteinDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-2487-6237
Tristan GlatardKrembil Centre for Neuroinformatics, The Centre for Addiction and Mental Health, Toronto, ON, Canada.
Michael P MilhamCenter for Data Analytics, Innovation, and Rigor, Child Mind Institute, New York, NY, USA.ORCID 0000-0003-3532-1210

Funding

Reproducible imaging-based brain growth charts for psychiatryR01MH120482 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MILHAM, MICHAEL PETER, SATTERTHWAITE, THEODORE · 2019 to 2023
$3.5M
Improving the robustness of neuroimaging through exploitation of variability in processing pipelinesRF1MH130859 · NIMH · CHILD MIND INSTITUTE, INC. · PI KIAR, GREGORY, MILHAM, MICHAEL PETER · 2022 to 2022
$1.5M
NIMH NIH HHS R01 MH120482NIMH NIH HHS RF1 MH130859U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH120482U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) RF1MH130859
6 · The paper itself

Abstract

In a perfect world, scientists would develop analyses that are guaranteed to reveal the ground truth of a research question. In reality, there are countless viable workflows that produce distinct, often conflicting, results. Although reproducibility places a necessary bound on the validity of results, it is not sufficient for claiming underlying validity, eventual utility, or generalizability. In this work we focus on how embracing variability in data analysis can improve the generalizability of results. We contextualize how design decisions in brain imaging can be made to capture variation, highlight examples, and discuss how variability capture may improve the quality of results.

Indexed as

BrainNeuroimagingHumansMagnetic Resonance ImagingReproducibility of ResultsResearch Design

Identifiers

PMID39482294
PMCPMC11528113

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.