Evidence map›Paper›PMID 39481289›Full record

ArticleUltrasonics sonochemistry2024

High precision acoustofluidic synthesis of stable, biocompatible water-in-water emulsions.

Kajal Sharma, Hao Deng, Parikshit Banerjee, Zaimao Peng, Jackson Gum, Alberto Baldelli, Jacek Jasieniak, Laurence Meagher, Mikaël M Martino, Venkat Gundabala and 1 more

Abstract read
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Article in Ultrasonics sonochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kajal SharmaDepartment of Mechanical and Aerospace Engineering, Monash University, Clayton, VIC 3800, Australia; Department of Chemical Engineering, Indian Institute of Technology (IIT) Bombay, Powai, Mumbai 400076, India.
Hao DengDepartment of Mechanical and Aerospace Engineering, Monash University, Clayton, VIC 3800, Australia; Department of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia.
Parikshit BanerjeeAustralian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia.
Zaimao PengDepartment of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia.
Jackson GumDepartment of Mechanical and Aerospace Engineering, Monash University, Clayton, VIC 3800, Australia.
Alberto BaldelliFaculty of Agriculture and Food Sustainability, The University of Queensland, St Lucia 4072, Queensland, Australia.
Jacek JasieniakDepartment of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia.
Laurence MeagherDepartment of Materials Science and Engineering, Monash University, Clayton, VIC 3800, Australia.
Mikaël M MartinoAustralian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia.
Venkat GundabalaDepartment of Chemical Engineering, Indian Institute of Technology (IIT) Bombay, Powai, Mumbai 400076, India.
Tuncay AlanDepartment of Mechanical and Aerospace Engineering, Monash University, Clayton, VIC 3800, Australia. Electronic address: tuncay.alan@monash.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Water-in-water (w/w) emulsions, comprising aqueous droplets within another continuous aqueous phase, rely on a low interfacial tension for stability. Thus far, it has been challenging to control their size and stability without the use of stabilizers. In this study, we introduce a microfluidic technique that addresses these challenges, producing stable w/w emulsions with precisely controlled size and uniformity. Results shows that using an acoustically actuated microfluidic mixer, PEG, Dextran, and alginate solutions (84.66 mPa.s viscosity difference) were homogenized rapidly, forming uniformly distributed w/w emulsions stabilized in alginate gels. The emulsion size, uniformity, and shear sensitivity can be tuned by modifying the alginate concentration. Biocompatibility was evaluated by monitoring the viability of kidney cells in the presence of emulsions and gels. In conclusion, this study not only showed emulsion formation with a high mixing efficiency exceeding 90 % for all viscosities, actuated at an optimized frequency of 1.064 MHz, but also demonstrated that an aqueous, solvent, and emulsifier-free composition exhibited remarkable biocompatibility, holding promise for precise drug delivery, cosmetics, and food applications.

Indexed as

Biocompatible MaterialsEmulsionsWaterAcousticsAlginatesCell SurvivalHumansPolyethylene GlycolsAlginatesBiocompatible MaterialsEmulsionsPolyethylene GlycolsWaterAcoustofluidicsAqueous two-phase systemsEmulsion encapsulationMicrofluidic mixerWater-in-water emulsions

Identifiers

PMID39481289
PMCPMC11564041

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.