ArticleChemistry & biodiversity2025
Unveiling the Substrate-Dependent Dynamics of Mycotoxin Production in Fusarium verticillioides Using an OSMAC-Metabolomics Approach.
Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- An Exploratory LC-HRMS Metabolomics Study of Culture Medium-Dependent Metabolic Variation and Bioactivity in Ten Fungal Strains.International journal of molecular sciences · 2026Article
- Biosynthesis Regulation of Secondary Metabolite Production inJournal of fungi (Basel, Switzerland) · 2025Review
- Unveiling the Substrate-Dependent Dynamics of Mycotoxin Production in Fusarium verticillioides Using an OSMAC-Metabolomics Approach.Chemistry & biodiversity · 2025Article
- Untargeted Metabolomics to Investigate the Influence of Epigenetic Modifiers on the Metabolism ofInternational journal of microbiology · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Fusarium verticillioides is a prevalent plant pathogenic fungus known to produce harmful mycotoxins, including fumonisins and emerging toxins. This study aimed to investigate the influence of substrate on the temporal patterns of mycotoxin biosynthesis by F. verticillioides, employing a combined OSMAC (One Strain-Many Compounds) strategy and metabolomics approach. The fungus was cultured under various media conditions, and samples were collected over time. LC-MS/MS analyses and a dereplicative workflow were used to profile the secondary metabolite production, focusing on mycotoxins. The results demonstrated that modifying the culture conditions led to significant variations in fungal growth and the nature and relative concentrations of mycotoxins produced. Corn meal agar (CMA) medium was favorable for fumonisins A
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Registered trials
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