Evidence map›Paper›PMID 39480801›Full record

ArticlePloS one2024

Exposure to air pollutants and subclinical carotid atherosclerosis measured by magnetic resonance imaging: A cross-sectional analysis.

Sandi M Azab, Dany Doiron, Karleen M Schulze, Jeffrey R Brook, Michael Brauer, Eric E Smith, Alan R Moody, Dipika Desai, Matthias G Friedrich, Shrikant I Bangdiwala and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Sandi M AzabDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Dany DoironResearch Institute of McGill University Health Centre, Montreal, Canada.
Karleen M SchulzeDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Jeffrey R BrookOccupational and Environmental Health Division, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Michael BrauerSchool of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, Canada.
Eric E SmithDepartment of Clinical Neurosciences, University of Calgary, Calgary, Alberta.
Alan R MoodyDepartment of Medical Imaging, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Dipika DesaiPopulation Health Research Institute, Hamilton, Ontario, Canada.
Matthias G FriedrichDepartment of Medicine and Diagnostic Radiology, McGill University, Montreal, Quebec, Canada.
Shrikant I BangdiwalaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Dena ZeraatkarDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America.
Douglas LeeProgramming and Biostatistics, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada.
Trevor J B DummerSchool of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, Canada.
Paul PoirierFaculté de Pharmacie, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, Quebec, Canada.
Jean-Claude TardifMontreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada.ORCID https://orcid.org/0000-0002-8200-8983
Koon K TeoDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Scott LearFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Salim YusufPopulation Health Research Institute, Hamilton, Ontario, Canada.
Sonia S AnandDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Russell J de SouzaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0001-8945-513X
Canadian Alliance of Healthy Hearts and Minds (CAHHM) Study Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesLong-term exposure to air pollution has been associated with higher risk of cardiovascular mortality. Less is known about the association of air pollution with initial development of cardiovascular disease. Herein, the association between low-level exposure to air pollutants and subclinical carotid atherosclerosis in adults without known clinical cardiovascular disease was investigated.

designCross-sectional analysis within a prospective cohort study.

settingThe Canadian Alliance for Healthy Hearts and Minds Cohort Study; a pan-Canadian cohort of cohorts.

participantsCanadian adults (n = 6645) recruited between 2014-2018 from the provinces of British Columbia, Alberta, Ontario, Quebec, and Nova Scotia, were studied, for whom averages of exposures to nitrogen dioxide (NO2), ozone (O3), and fine particulate matter (PM2.5) were estimated for the years 2008-2012.

main outcome measureCarotid vessel wall volume (CWV) measured by magnetic resonance imaging (MRI).

resultsIn adjusted linear mixed models, PM2.5 was not consistently associated with CWV (per 5 μg/m3 PM2.5; adjusted estimate = -8.4 mm3; 95% Confidence Intervals (CI) -23.3 to 6.48; p = 0.27). A 5 ppb higher NO2 concentration was associated with 11.8 mm3 lower CWV (95% CI -16.2 to -7.31; p<0.0001). A 3 ppb increase in O3 was associated with 9.34 mm3 higher CWV (95% CI 4.75 to 13.92; p<0.0001). However, the coarse/insufficient O3 resolution (10 km) is a limitation.

conclusionsIn a cohort of healthy Canadian adults there was no consistent association between PM2.5 or NO2 and increased CWV as a measure of subclinical atherosclerosis by MRI. The reasons for these inconsistent associations warrant further study.

Indexed as

Air PollutantsCarotid Artery DiseasesMagnetic Resonance ImagingOzoneParticulate MatterAdultAgedAir PollutionCanadaCross-Sectional StudiesEnvironmental ExposureFemaleHumansMaleMiddle AgedNitrogen DioxideAir PollutantsNitrogen DioxideOzoneParticulate Matter

Identifiers

PMID39480801
PMCPMC11527219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.