Evidence map›Paper›PMID 39480688›Full record

ArticleChemSusChem2025

Xylose Acetals - a New Class of Sustainable Solvents and Their Application in Enzymatic Polycondensation.

Anastasia O Komarova, Cicely M Warne, Hugo Pétremand, Laura König-Mattern, Johannes Stöckelmaier, Chris Oostenbrink, Georg M Guebitz, Jeremy Luterbacher, Alessandro Pellis

Abstract read
In one paragraph

Article in ChemSusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anastasia O KomarovaLaboratory of Sustainable and Catalytic Processing, Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Station 6, 1015, Lausanne, Switzerland.
Cicely M Warneacib GmbH, Konrad-Lorenz-Strasse 20, 3430, Tulln an der Donau, Austria.
Hugo PétremandLaboratory of Sustainable and Catalytic Processing, Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Station 6, 1015, Lausanne, Switzerland.
Laura König-MatternMax Planck Institute for Dynamics of Complex Technical Systems, Process Systems Engineering (PSE), Sandtorstraße 1, D-39106, Magdeburg, Germany.
Johannes StöckelmaierInstitute of Molecular Modeling and Simulation (MMS), University of Natural Resources and Life Sciences Vienna, Muthgasse 18, 1190, Vienna, Austria.
Chris OostenbrinkInstitute of Molecular Modeling and Simulation (MMS), University of Natural Resources and Life Sciences Vienna, Muthgasse 18, 1190, Vienna, Austria.
Georg M Guebitzacib GmbH, Konrad-Lorenz-Strasse 20, 3430, Tulln an der Donau, Austria.
Jeremy LuterbacherLaboratory of Sustainable and Catalytic Processing, Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL), Station 6, 1015, Lausanne, Switzerland.
Alessandro PellisUniversitá di Genova, Dipartimento di Chimica e Chimica Industriale, via Dodecaneso 31, 16146, Genova (GE), Italy.ORCID 0000-0003-3711-3087

Funding

European Union's Horizon 2020 researchEuropean Union's Horizon 2020 research 953073Marie Skłodowska-Curie 945363NCCR Catalysis 180544Swiss National Science Foundation 200021_182605Swiss National Science Foundation CRSII5_180258UPLIFT
6 · The paper itself

Abstract

The use of organic solvents in academic research and industry applications is facing increasing regulatory pressure due to environmental and health concerns. Consequently, there is a growing demand for sustainable solvents, particularly in the enzymatic synthesis and processing of polyesters. Biocatalysts offer a sustainable method for producing these materials; however, achieving high molecular weights often necessitates use of solvents. In this work, we introduce a new class of alternative aprotic solvents with medium polarity produced directly from agricultural waste biomass in up to 83 mol % yield (on xylan basis). The new solvents have a largely unmodified xylose core and acetal functionality, yet they show no peroxide formation and provide reduced flammability risk. We also demonstrate their successful application in enzymatic polycondensation reactions with Candida antarctica lipase B (CaLB). In particular, the solvent dibutylxylose (DBX) outperformed the hazardous solvent diphenyl ether and facilitated polycondensation of the lignin-derived diester pyridine-2,4-dicarboxylate, yielding polyesters with a M

Indexed as

AcetalsFungal ProteinsLipaseSolventsXyloseGreen Chemistry TechnologyPolyestersAcetalsFungal ProteinsLipaselipase B, Candida antarcticaPolyestersSolventsXyloseBiocatalysisBiomass valorisationGreen chemistryPolymersSolventXylose

Identifiers

PMID39480688
PMCPMC11911975

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.