Evidence map›Paper›PMID 39480277›Full record

ArticleThe British journal of psychiatry : the journal of mental science2025

Breast cancer risk among women with schizophrenia and association with duration of antipsychotic use: population-based cohort study in South Korea.

Ji Su Yang, Sunghyuk Kang, Kwanghyun Kim, Alexander C Tsai, Chul-Hyun Cho, Sun Jae Jung

Abstract read
In one paragraph

Article in The British journal of psychiatry : the journal of mental science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ji Su YangDepartment of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5070-6923
Sunghyuk KangDepartment of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.
Kwanghyun KimDepartment of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.
Alexander C TsaiHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-6397-7917
Chul-Hyun ChoDepartment of Psychiatry, Korea University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-1663-9680
Sun Jae JungDepartment of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-5194-7339

Funding

Mentoring in patient-oriented research on the U.S. substance use and HIV syndemicK24DA061696 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI ALEXANDER C TSAI · 2024 to 2026
$640k
National Research Foundation of Korea 2020R1C1C1003502NIDA NIH HHS K24 DA061696
6 · The paper itself

Abstract

backgroundBreast cancer is a major global health issue, especially among women. Previous research has indicated a possible association between psychiatric conditions, particularly schizophrenia, and an increased risk of breast cancer. However, the specific risk of breast cancer in women with schizophrenia, compared with those with other psychiatric disorders and the general population, remains controversial and needs further clarification.

aimsTo estimate the risk of breast cancer among people with schizophrenia compared with people with other psychiatric disorders and people in the general population.

methodWe utilised medical claims data of women aged 18 to 80 years in the Korean National Health Information Database from 2007 to 2018. Individuals with schizophrenia were defined as women with ICD-10 codes F20 or F25 (

resultsIn multivariable Cox regression models, the hazard rate of breast cancer was 1.26 times higher in the people with schizophrenia than in the general population (95% CI: 1.20-1.32). In comparison with the psychiatric patient group, the hazard ratio was 1.17 (95% CI: 1.11-1.28). Among women with schizophrenia, the hazard of breast cancer was greater among those who took antipsychotic medications for 1 year or more compared with those who took antipsychotics for less than 6 months.

conclusionsWomen with schizophrenia have an elevated risk of breast cancer, and long-term use of antipsychotics is associated with an increased risk of breast cancer.

Indexed as

Antipsychotic AgentsBreast NeoplasmsSchizophreniaAdolescentAdultAgedAged, 80 and overCohort StudiesFemaleHumansMiddle AgedRepublic of KoreaRisk FactorsYoung AdultAntipsychotic Agentsantipsychoticsbreast cancerepidemiologyPsychotic disorders/schizophreniasurvival analysis

Identifiers

PMID39480277
PMCPMC12038387

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.