Evidence map›Paper›PMID 39479945›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2025

Amide proton transfer MRI may reflect effective reperfusion and predict functional outcomes in patients with ischemic stroke.

Chi Zhang, Xingwang Yong, Yuezhou Cao, Yi-Cheng Hsu, Haibin Shi, Feiyun Wu, Yi Zhang, Shanshan Lu

Abstract read
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In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chi ZhangDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xingwang YongKey Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China.
Yuezhou CaoDepartment of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yi-Cheng HsuMR Collaboration, Siemens Healthcare Ltd., Shanghai, China.
Haibin ShiDepartment of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Feiyun WuDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yi ZhangKey Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China.
Shanshan LuDepartment of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID 0009-0003-4213-9908

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perfusion imaging is useful to assess tissue recovery in patients with acute ischemic stroke (AIS); however, it cannot reflect tissue metabolism. We postulated that amide proton transfer (APT) imaging can characterize the tissue status after reperfusion therapy, thus providing prognostic value for 90-day functional outcomes. We included 63 patients with AIS and large-vessel occlusion (LVO). The APT signals, including APT

Indexed as

AmidesIschemic StrokeMagnetic Resonance ImagingReperfusionAgedAged, 80 and overDiffusion Magnetic Resonance ImagingFemaleHumansMaleMiddle AgedPrognosisProtonsTreatment OutcomeAmidesProtonsacidosisamide proton transferIschemic strokeperfusionprognosis

Identifiers

PMID39479945
PMCPMC11846100

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.