Evidence map›Paper›PMID 39479675›Full record

ArticleFood science & nutrition2024

The effect of astaxanthin after varicocele surgery on antioxidant status and semen quality in infertile men: A triple-blind randomized clinical trial.

Shimal Ayub Mohammed Salih, Masoome Jabarpour, Mohammad Ali Sedighi Gilani, Hesamoddin Sajadi, Mojtaba Saedi Marghmaleki, Maryam Shabani Nashtaei, Maryam Salem, Fardin Amidi

Abstract read
In one paragraph

Article in Food science & nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shimal Ayub Mohammed SalihDepartment of Anatomy, School of Medicine Tehran University of Medical Sciences Tehran Iran.
Masoome JabarpourDepartment of Anatomy, School of Medicine Tehran University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0001-9020-8304
Mohammad Ali Sedighi GilaniDepartment of Infertility, Shariati Hospital Tehran University of Medical Sciences Tehran Iran.
Hesamoddin SajadiDepartment of Andrology, Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine, ACECR Tehran Iran.
Mojtaba Saedi MarghmalekiDepartment of Anatomy, School of Medicine Tehran University of Medical Sciences Tehran Iran.
Maryam Shabani NashtaeiDepartment of Anatomy, School of Medicine Tehran University of Medical Sciences Tehran Iran.
Maryam SalemDepartment of Anatomy, School of Medicine Tehran University of Medical Sciences Tehran Iran.
Fardin AmidiDepartment of Anatomy, School of Medicine Tehran University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0000-0003-1165-5232

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Varicocele (VC) is widely recognized as a prevalent etiological factor contributing to male infertility. It has been established that the generation of reactive oxygen species (ROS) plays a significant role in the progression and development of VC. Antioxidants may regulate ROS levels in these patients. Astaxanthin (ASX) is a carotenoid compound with notable antioxidant and anti-inflammatory characteristics. The current study postulated that the administration of ASX following varicocelectomy (VCT) could potentially enhance antioxidant status and semen quality in these patients. A total of 40 infertile males with clinical VC and abnormal semen analyses were randomly assigned to take part in the current trial. For 3 months following surgery, the intervention group took ASX (6 mg/day) while the control group received a placebo. After intervention, semen parameters,

Indexed as

antioxidant statusastaxanthinpro‐inflammatory cytokinessemen parametersvaricocelevaricocelectomy

Identifiers

PMID39479675
PMCPMC11521721

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.