Evidence map›Paper›PMID 39479497›Full record

ArticleRSC advances2024

Perturbation of hyperthermia resistance in gastric cancer by hyperstimulation of autophagy using artemisinin-protected iron-oxide nanoparticles.

Komal Attri, Bhupendra Chudasama, Roop L Mahajan, Diptiman Choudhury

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Komal AttriDepartment of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology Patiala 147004 Punjab India diptiman@thapar.edu +91-8196949843.
Bhupendra ChudasamaDepartment of Physics and Material Sciences, Thapar Institute of Engineering and Technology Patiala 147004 Punjab India bnchudasama@thapar.edu +91-9781966136.
Roop L MahajanDepartment of Mechanical Engineering, Department of Materials Science & Engineering, Virginia Tech Blacksburg VA 24061 USA mahajanr@vt.edu +1-5402312597.
Diptiman ChoudhuryDepartment of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology Patiala 147004 Punjab India diptiman@thapar.edu +91-8196949843.ORCID https://orcid.org/0000-0003-1080-4558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a bid to overcome hyperthermia resistance, a major obstacle in cancer treatment, this study explores manipulating autophagy, a cellular recycling mechanism, within the context of gastric cancer. We designed artemisinin-protected magnetic iron-oxide nanoparticles (ART-MNPs) to hyperactivate autophagy, potentially sensitizing cancer cells to hyperthermia. The synthesized ART-MNPs exhibited magnetic properties and the capability of raising the temperature by 7 °C at 580.3 kHz. Importantly, ART-MNPs displayed significant cytotoxicity against human gastric cancer cells (AGS), with an IC50 value of 1.9 μg mL

Identifiers

PMID39479497
PMCPMC11520311

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.