Evidence map›Paper›PMID 39479490›Full record

ArticleRSC advances2024

Levoglucosenone as a starting material for cascade continuous-flow synthesis of (R)-γ-carboxy-γ-butyrolactone.

Caio M Pacheco, Wesley Lima, Fernanda A Lima, Mauro R B P Gomez, Isabela G da Silva, Leandro S M Miranda, Pierre M Esteves, Ivaldo Itabaiana, Robert Wojcieszak, Raquel A C Leão and 1 more

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Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Caio M PachecoBiocatalysis and Organic Synthesis Group, Chemistry Institute, Federal University of Rio de Janeiro Rio de Janeiro 21941910 Brazil.ORCID https://orcid.org/0000-0002-0022-9708
Wesley LimaBiocatalysis and Organic Synthesis Group, Chemistry Institute, Federal University of Rio de Janeiro Rio de Janeiro 21941910 Brazil.
Fernanda A LimaBiocatalysis and Organic Synthesis Group, Chemistry Institute, Federal University of Rio de Janeiro Rio de Janeiro 21941910 Brazil.
Mauro R B P GomezBiocatalysis and Organic Synthesis Group, Chemistry Institute, Federal University of Rio de Janeiro Rio de Janeiro 21941910 Brazil.
Isabela G da SilvaBiocatalysis and Organic Synthesis Group, Chemistry Institute, Federal University of Rio de Janeiro Rio de Janeiro 21941910 Brazil.
Leandro S M MirandaBiocatalysis and Organic Synthesis Group, Chemistry Institute, Federal University of Rio de Janeiro Rio de Janeiro 21941910 Brazil.
Pierre M EstevesInstituto de Química, Universidade Federal do Rio de Janeiro Av. Athos da Silveira Ramos, 149, CT, A-622, Cid. Univ. Rio de Janeiro RJ 21941-909 Brazil.ORCID https://orcid.org/0000-0001-6048-4690
Ivaldo ItabaianaDepartment of Biochemical Engineering, School of Chemistry, Federal University of Rio de Janeiro Rio de Janeiro 21941909 Brazil.
Robert WojcieszakUniv. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181 - UCCS - Unité de Catalyse et Chimie du Solide Lille France.ORCID https://orcid.org/0000-0002-8956-5846
Raquel A C LeãoBiocatalysis and Organic Synthesis Group, Chemistry Institute, Federal University of Rio de Janeiro Rio de Janeiro 21941910 Brazil.
Rodrigo O M A de SouzaBiocatalysis and Organic Synthesis Group, Chemistry Institute, Federal University of Rio de Janeiro Rio de Janeiro 21941910 Brazil.ORCID https://orcid.org/0000-0002-6422-4025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global imperative to shift towards renewable and sustainable resources has spurred significant interest in exploring and utilizing platform chemicals derived from renewable feedstocks. Among these, levoglucosenone (LGO) and Cyrene™ have emerged as promising candidates. LGO, derived from the pyrolysis of cellulose and hemicellulose, exhibits structural versatility, making it an attractive starting material for various valuable products. Its chemical transformations can yield a diverse array of derivatives, including levulinic acid, furan derivatives, and intermediates for pharmaceutical and agrochemical synthesis, as well as bio-based materials such as bioplastics and resins. Cyrene™, produced through the hydrogenation of LGO, serves as a renewable, biodegradable, and non-toxic dipolar aprotic solvent, offering sustainability advantages for green chemistry applications. Herein we report our results on the continuous-flow cascade transformation of LGO into Cyrene™ and then (R)-γ-carboxy-γ-butyrolactone in good yields with an additional mechanistic investigation for the Baeyer-Villiger oxidation of Cyrene™.

Identifiers

PMID39479490
PMCPMC11521107

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.