Evidence map›Paper›PMID 39479397›Full record

ArticleFrontiers in genetics2024

Bta-miR-665 improves bovine blastocyst development through its influence on microtubule dynamics and apoptosis.

Xuefeng Guan, Yuan Fan, Rani Six, Camilla Benedetti, Annelies Raes, Andrea Fernandez Montoro, Xiaole Cui, Nima Azari Dolatabad, Ann Van Soom, Krishna Chaitanya Pavani and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Role of miRNAs in Bovine Oocyte Maturation and Reproductive Regulation.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xuefeng GuanDepartment of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Yuan FanDepartment of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Rani SixDepartment of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Camilla BenedettiDepartment of Internal Medicine, Reproduction and Population Health, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium.
Annelies RaesDepartment of Internal Medicine, Reproduction and Population Health, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium.
Andrea Fernandez MontoroDepartment of Internal Medicine, Reproduction and Population Health, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium.
Xiaole CuiDepartment of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
Nima Azari DolatabadDepartment of Internal Medicine, Reproduction and Population Health, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium.
Ann Van SoomDepartment of Internal Medicine, Reproduction and Population Health, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium.
Krishna Chaitanya PavaniDepartment of Internal Medicine, Reproduction and Population Health, Faculty of Veterinary Medicine, University of Ghent, Merelbeke, Belgium.
Luc PeelmanDepartment of Veterinary and Biosciences, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) contain microRNAs (miRNAs), which are important regulators of embryonic development. Nevertheless, little is known about the precise molecular processes controlling blastocyst development and quality. In a previous study, we identified bta-miR-665 as one of the miRNAs more abundantly present in extracellular vesicles of embryo-conditioned culture media of blastocysts compared to degenerate ones. Here, we investigated the effect and regulatory roles of bta-miR-665 in blastocyst development by supplementation of bta-miR-665 mimics or inhibitors to the culture media. Supplementation of bta-miR-665 mimics improved cleavage and blastocyst rate (

Indexed as

blastocyst formationcell proliferationembryo developmentMicroRNAsmicrotubules

Identifiers

PMID39479397
PMCPMC11521815

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.