Evidence map›Paper›PMID 39479393›Full record

ArticleFrontiers in cardiovascular medicine2024

Inhibition of angiogenesis and regenerative lung growth in

Tendai Hunyenyiwa, Priscilla Kyi, Mikaela Scheer, Mrudula Joshi, Mario Gasparri, Tadanori Mammoto, Akiko Mammoto

Abstract read
In one paragraph

Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Angiogenesis in Lung Regeneration and Aging.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tendai HunyenyiwaDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.
Priscilla KyiDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.
Mikaela ScheerDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.
Mrudula JoshiDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.
Mario GasparriDepartment of Thoracic Surgery, Medical College of Wisconsin, Milwaukee, WI, United States.
Tadanori MammotoDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.
Akiko MammotoDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.

Funding

The role of YAP1 in angiogenesis during organ regenerationR01HL142578 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MAMMOTO, AKIKO, MAMMOTO, TADANORI · 2019 to 2022
$1.5M
Role of endothelial Twist1 in vascular remodeling in pulmonary hypertensionR01HL139638 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MAMMOTO, AKIKO, MAMMOTO, TADANORI · 2019 to 2022
$1.2M
American Heart Association-American Stroke Association 18TPA34170129American Heart Association-American Stroke Association 967800NHLBI NIH HHS R01 HL139638NHLBI NIH HHS R01 HL142578
6 · The paper itself

Abstract

Introduction: Obesity is associated with impairment of wound healing and tissue regeneration. Angiogenesis, the formation of new blood capillaries, plays a key role in regenerative lung growth after unilateral pneumonectomy (PNX). We have reported that obesity inhibits angiogenesis. The effects of obesity on post-PNX lung vascular and alveolar regeneration remain unclear. Methods: Unilateral PNX is performed on Results: Regenerative lung growth and expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR2 induced after PNX are inhibited in Discussion: These findings suggest that obesity impairs lung vascular and alveolar regeneration and adiponectin is one of the key factors to improve lung regeneration in obese people.

Indexed as

adiponectinangiogenesislung regenerationobesityVEGF

Identifiers

PMID39479393
PMCPMC11521822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.