Evidence map›Paper›PMID 39479325›Full record

ArticleJACC. CardioOncology2024

Adiposity and Muscle Strength in Men With Prostate Cancer and Cardiovascular Outcomes.

Darryl P Leong, Vincent Fradet, Tamim Niazi, Joseph B Selvanayagam, Robert Sabbagh, Celestia S Higano, Steven Agapay, Sumathy Rangarajan, Rajibul Mian, Carlos A K Nakashima and 29 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. CardioOncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Influence of androgen deprivation therapy on physical performance and muscle strength in prostate cancer patients - a systematic review.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Review
  8. Review
  9. Article
  10. Cardiovascular Risk in Prostate Cancer:JACC. CardioOncology · 2024
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Darryl P LeongPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
Vincent FradetCentre de Recherche du CHU de Québec, Université Laval, Quebec City, Quebec, Canada.
Tamim NiaziJewish General Hospital, Montreal, Quebec, Canada.
Joseph B SelvanayagamSouthern Area Local Health Network and Flinders University of South Australia, Adelaide, Australia.
Robert SabbaghFaculty of Medicine, University of Sherbrooke, Montreal, Quebec, Canada.
Celestia S HiganoUniversity of British Columbia and Madrona Oncology, Seattle, Washington, USA.
Steven AgapayPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
Sumathy RangarajanPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
Rajibul MianPopulation Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
Carlos A K NakashimaFaculdades Pequeno Príncipe, Sociedade Hospitalar Angelina Caron, Araçatuba, Brazil.
Negareh MousaviMcGill University Health Centre, Montreal, Quebec, Canada.
Ian BrownDivision of Urology, Niagara Health System, St. Catharines, Ontario, Canada.
Felipe H ValleDivision of Cardiology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Luke T LavalléeDivision of Urology, University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Bobby ShayeganDivision of Urology, Department of Surgery, St. Joseph's Healthcare Hamilton and McMaster University, Hamilton, Ontario, Canada.
Kelvin K H NgDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Darin D GopaulGrand River Regional Cancer Centre, Kitchener, Ontario, Canada.
Germano D CavalliDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Sonia SaavedraFaculty of Medicine, University of La Frontera, Temuco, Chile.
Jose P Lopez-LopezMasira Research Institute, Universidad de Santander, Bucaramanga, Colombia.
Cristiano Freitas de SouzaNúcleo de Pesquisa Clínica - Rede São Camilo and Instituto Brasileiro de Controle do Cancer, São Paolo, Brazil.
Emmanuelle DuceppeDepartment of Medicine, Centre Hospitalier de l'Université de Montreal, Montreal, Quebec, Canada.
Lívia F Avezum OliveiraCentro de Pesquisa Clínica do HC-UFTM, Uberaba, Brazil.
Avirup GuhaAugusta University, Augusta, Georgia, USA.
Juan Esteban Gomez-MesaDepartment of Health Sciences and Fundacíon Valle del Lili, Universidad Icesi, Cali, Colombia.
Luis Eduardo Silva MózClinical Oncology Department, Santa Casa de São Paolo Hospital, São Paolo, Brazil.
Philippe D VioletteWoodstock Hospital, McMaster University, Woodstock, Ontario, Canada.
Álvaro AvezumInternational Research Center, Hospital Alemão Oswaldo Cruz, São Paolo, Brazil.
Gustavo B F OliveiraInternational Research Center, Hospital Alemão Oswaldo Cruz, São Paolo, Brazil.
Ariel G KannInternational Research Center, Hospital Alemão Oswaldo Cruz, São Paolo, Brazil.
Edilson WalterCentro de Oncologia do Hospital de Clínicas Ijuí, Ijuí, Brazil.
Cesar O L DusilekHospital Rocio, Curitiba, Brazil.
Nicolas Villareal TrujilloFOSCAL Internacional Clinic, Floridablanca, Colombia.
Patricia BeatoCentro de Pesquisas Clínicas da Fundação Doutor Amaral Carvalho, São Paolo, Brazil.
Ludhmila A HajjarFaculdade de Medicina da Universidade de São Paolo, São Paolo, Brazil.
Patrick P W LukeDepartment of Surgery, London Health Science Centre, London, Ontario, Canada.
Eduardo SchlabendorffMãe de Deus Hospital, Porto Alegre, Brazil.
David SaridTel Aviv Sourasky Medical Centre, Tel Aviv, Israel.
Jehonathan PinthusDepartment of Surgery, McMaster University, Hamilton, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There are limited data on the physical effects of androgen deprivation therapy (ADT) for prostate cancer (PC), and on the relationships of such measures of adiposity and strength to cardiovascular outcomes. Objectives: The primary objective of this study was to evaluate the relationships of measures of adiposity and strength to cardiovascular outcomes (cardiovascular death, myocardial infarction, stroke, heart failure, arterial revascularization, peripheral arterial disease, and venous thromboembolism) in patients with PC. A secondary objective was to characterize the relationships between ADT use and 12-month changes in these physical measures. Methods: This international, prospective cohort study included 3,967 patients with PC diagnosed in the prior 12 months or being treated with ADT for the first time. Median follow-up duration was 2.3 years. Results: Participants' mean age was 68.5 years, and 1,731 (43.6%) were exposed to ADT. ADT was associated with a 1.6% increase in weight, a 2.2% increase in waist circumference, a 1.6% increase in hip circumference, a 0.1% increase in waist-to-hip ratio, a 27.4% reduction in handgrip strength, and a 0.1% decrease in gait speed. High waist circumference and low handgrip strength were associated with adverse cardiovascular outcomes. Adjusting for age, education, race, tobacco and alcohol use, physical activity, cardiovascular disease, glomerular filtration rate, and ADT use, waist circumference above the highest quartile (110 cm) and handgrip strength below the lowest quartile (29.5 kg) were associated with higher likelihoods of a future cardiovascular event, with respective HRs of 1.40 (95% CI: 1.03-1.90; Conclusions: ADT was associated with increased adiposity and reduced strength over 12-month follow-up. High waist circumference and low baseline strength were associated with future adverse cardiovascular outcomes.

Indexed as

adiposityandrogen deprivation therapycardiovascularmuscle strengthobesityprostate cancer

Identifiers

PMID39479325
PMCPMC11520207

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.