Evidence map›Paper›PMID 39479313›Full record

ArticleJACC. CardioOncology2024

Life's Essential 8 and Incident Cardiovascular Disease in U.S. Women With Breast Cancer.

Elena Wadden, Alexi Vasbinder, Vidhushei Yogeswaran, Aladdin H Shadyab, Nazmus Saquib, Yangbo Sun, Lisa Warsinger Martin, Ramesh Mazhari, JoAnn E Manson, Marcia Stefanick and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. CardioOncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A Systematic Review of Cardiovascular Health Among Cancer Survivors.International journal of environmental research and public health · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elena WaddenDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Alexi VasbinderDepartment of Biobehavioral Nursing and Health Informatics, University of Washington School of Nursing, Seattle, Washington, USA.
Vidhushei YogeswaranDivision of Cardiology, University of Washington, Seattle, Washington, USA.
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science and Division of Geriatrics, Gerontology, and Palliative Care, Department of Medicine, University of California-San Diego, La Jolla, California, USA.
Nazmus SaquibCollege of Medicine, Sulaiman AlRajhi University, Al Bukayriyah, Saudi Arabia.
Yangbo SunDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Lisa Warsinger MartinDivision of Cardiology, George Washington University School of Medicine, Washington, DC, USA.
Ramesh MazhariDivision of Cardiology, George Washington University School of Medicine, Washington, DC, USA.
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Marcia StefanickDepartment of Medicine, Stanford University, Stanford, California, USA.
Ana BaracInova Schar Heart and Vascular, Falls Church, Virginia, USA.
Michael S SimonKarmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.
Kerryn RedingDepartment of Biobehavioral Nursing and Health Informatics, University of Washington School of Nursing, Seattle, Washington, USA.
Richard K ChengDivision of Cardiology, University of Washington, Seattle, Washington, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Relationships between lifestyle risk factors and cardiovascular disease (CVD) risk in women with breast cancer (BC) are underexplored. Objectives: To evaluate the incidence of CVD in relation to the Life's Essential 8 (LE8) score among women with BC. Methods: Data from the Women's Health Initiative were utilized. The primary exposure was the LE8 score assessed prior to BC diagnosis. The LE8 score was stratified into low (0-59), moderate (60-79), and high (80-100) cardiovascular health (CVH). The primary endpoint was a composite of incident CVD events, which included coronary heart disease, defined as myocardial infarction along with coronary revascularization, CVD death, and stroke. We calculated the cumulative incidence of CVD and estimated hazard ratios. Results: Among 7,165 participants, the median age was 70.1 years at BC diagnosis. The mean LE8 score was 62.0 ± 12.2. Over a median follow-up period of 6 years, 490 composite CVD events occurred. The risk of CVD events was highest for low CVH compared with moderate and high CVH. Compared with low CVH, the hazard ratio for incident CVD was 0.57 (95% CI: 0.46-0.69) for moderate CVH and 0.34 (95% CI: 0.20-0.59) for high CVH. LE8, in conjunction with age, provided a C-statistic of 0.74 for the composite risk of CVD. Conclusions: Higher LE8 scores were associated with a lower risk of incident CVD among women with BC in the United States.

Indexed as

behavioral risk factorsbreast cancerischemic diseaselifestyle risk factorswomen’s oncology

Identifiers

PMID39479313
PMCPMC11520208

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.