Evidence map›Paper›PMID 39479249›Full record

ArticleRoyal Society open science2024

β-Defensin gene copy number variation in cattle.

Ozge Sidekli, John Oketch, Sean Fair, Kieran G Meade, Edward J Hollox

Abstract read
In one paragraph

Article in Royal Society open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. β-Defensin gene copy number variation in cattle.Royal Society open science · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ozge SidekliDepartment of Genetics and Genome Biology, University of Leicester, Leicester, UK.
John OketchDepartment of Genetics and Genome Biology, University of Leicester, Leicester, UK.
Sean FairDepartment of Biological Sciences, Bernal Institute, Faculty of Science and Engineering, University of Limerick, Limerick, Ireland.
Kieran G MeadeSchool of Agriculture and Food Science, University College Dublin, Dublin, Ireland.
Edward J HolloxDepartment of Genetics and Genome Biology, University of Leicester, Leicester, UK.ORCID https://orcid.org/0000-0002-0115-2298

Funding

Wellcome Trust
6 · The paper itself

Abstract

β-Defensins are peptides with antimicrobial roles, characterized by a conserved tertiary structure. Beyond antimicrobial functions, they exhibit diverse roles in both the immune response and fertility, including involvement in sperm maturation and function. Copy number variation (CNV) of β-defensin genes is extensive across mammals, including cattle, with possible implications for reproductive traits and disease resistance. In this study, we comprehensively catalogue 55 β-defensin genes in cattle. By constructing a phylogenetic tree to identify human orthologues and lineage-specific expansions, we identify 1 : 1 human orthologues for 35 bovine β-defensins. We also discover extensive β-defensin gene CNV across breeds, with

Indexed as

bullcattlecopy number variationDEFB103fertilityβ-defensins

Identifiers

PMID39479249
PMCPMC11521603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.