Evidence map›Paper›PMID 39479176›Full record

ArticleInternational journal of nanomedicine2024

Three-in-One Nanozyme for Radiosensitization of Bladder Cancer.

Yang Li, Yuhan Zhang, Na Feng, Fan Yu, Bin Liu

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Multifunctional CuFrontiers in chemistry · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yang LiDepartment of Gastroenterology and Hepatology, China-Japan Union Hospital of Jilin University, Changchun, 130033, People's Republic of China.
Yuhan ZhangDepartment of Gastroenterology and Hepatology, China-Japan Union Hospital of Jilin University, Changchun, 130033, People's Republic of China.
Na FengDepartment of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People's Republic of China.
Fan YuDepartment of Gastroenterology and Hepatology, China-Japan Union Hospital of Jilin University, Changchun, 130033, People's Republic of China.
Bin LiuDepartment of Urology, China-Japan Union Hospital of Jilin University, Changchun, 130033, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Bladder cancer is a common malignancy of the urinary system and the development of noninvasive therapeutic methods is imperative to avoid radical cystectomy, which results in a poor quality of life for patients. Methods: In this study, ultrasmall copper-palladium nanozymes decorated with cysteamine (CPC) nanoparticles (NPs) were synthesized to enhance the efficacy of radiotherapy (RT) in treating bladder cancer. CPC NPs react with intracellular overexpressed H Results: The results demonstrate an increased level of ROS and an elevation in oxygen content at the tumor site. Importantly, tumor growth was restrained without apparent systemic toxicity during the combined treatment. Conclusion: In summary, this study highlights the potential of CPC nanozyme-mediated radiotherapy as a promising avenue for the effective treatment of bladder cancer and demonstrates its potential for future clinical applications in the synergistic therapy of bladder cancer.

Indexed as

CopperPalladiumRadiation-Sensitizing AgentsReactive Oxygen SpeciesUrinary Bladder NeoplasmsAnimalsApoptosisCell Line, TumorGlutathioneHumansHydrogen PeroxideMetal NanoparticlesMiceMice, Inbred BALB CNanoparticlesTumor MicroenvironmentCopperGlutathioneHydrogen PeroxidePalladiumRadiation-Sensitizing AgentsReactive Oxygen Speciesbladder cancerhypoxiananozymeradiotherapytumor microenvironment

Identifiers

PMID39479176
PMCPMC11523926

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.