ArticleCureus2024
The Overtreatment Trap: Navigating Dopamine Dysregulation Syndrome in Parkinson's Disease.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine dysregulation syndrome (DDS) is a rare but significant complication of Parkinson's disease (PD), affecting approximately 3-4% of patients on long-term dopamine replacement therapy (DRT). It is characterized by an addictive pattern of DRT use that exceeds the necessary dosages for managing motor symptoms. Patients may engage in self-medication, escalating their DRT doses beyond prescribed limits, and strongly resist attempts to reduce medication. This syndrome often leads to impulsive behaviors, severe dyskinesia, and notable disruptions in social and occupational functioning. DDS is associated with a range of neuropsychiatric symptoms, including punding behaviors, hallucinations, and delusions. The management of DDS presents significant challenges, requiring a delicate balance between adequate symptom control and preventing medication overuse. We present a case of a 68-year-old woman with DDS, highlighting her symptoms and the tailored management strategies we employed to address this challenging condition.
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