Evidence map›Paper›PMID 39478958›Full record

ReviewFrontiers in pharmacology2024

Flavonoids against depression: a comprehensive review of literature.

Alaleh Alizadeh, Yeganeh Pourfallah-Taft, Maryam Khoshnazar, Aysan Safdari, Saba Vafadar Komari, Mehrnaz Zanganeh, Nafiseh Sami, Maryam Valizadeh, Arezoo Faridzadeh, Dorsa Alijanzadeh and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Biochemistry and biophysics reports · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alaleh AlizadehStudent Research Committee, Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Yeganeh Pourfallah-TaftStudent's Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Maryam KhoshnazarStudent Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Aysan SafdariStudent Research Committee, Faculty of Nursing and Midwifery, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Saba Vafadar KomariStudent Research Committee, Faculty of Nursing and Midwifery, Tabriz Branch, Islamic Azad University, Tabriz, Iran.
Mehrnaz ZanganehStudent Research Committee, Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Nafiseh SamiStudent Research Committee, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Maryam ValizadehDental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Arezoo FaridzadehDepartment of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Dorsa AlijanzadehStudent's Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Amirhossein MazhariStudent Research Committee, Azerbaijan Medical University, Baku, Azerbaijan.
Reza KhademiStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Ali KheirandishStudent Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Mahdyieh NaziriStudents Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Depression is a state of low mood and aversion to activity, which affects a person's thoughts, behavior, motivation, feelings, and sense of wellbeing. Pharmacologic therapies are still the best effective treatment of depression. Still, most antidepressant drugs have low efficacy and delayed onset of therapeutic action, have different side effects, and even exacerbate depression. Such conditions make it possible to look for alternatives. Consequently, we decided to summarize the impact of flavonoids on depression in this review. Methods: We searched scientific databases such as SCOPUS, PubMed, and Google Scholar to find relevant studies until July 2022. Results: A wide variety of natural components have been shown to alleviate depression, one of which is flavonoids. Due to the growing tendency to use natural antidepressant drugs, scientific studies are increasingly being conducted on flavonoids. This study aims to review the latest scientific researches that indicate the antidepressant potential of flavonoids. Various mechanisms include neurotransmitter system modulation and dopaminergic, noradrenergic, and serotonergic pathways regulation in the central nervous system. Different compounds of flavonoids have antidepressant properties Conclusion: Our study proves the antidepressant potential of flavonoids, and considering the limited side effects, they can be used as complementary medicine for depressed patients.

Indexed as

complementary medicineIntroductiondepressionflavonoidsherbal medicineIran antidepressantnatural productstehran hemat highway next to milad Tower14535

Identifiers

PMID39478958
PMCPMC11521854

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.