Evidence map›Paper›PMID 39478950›Full record

ReviewIranian journal of child neurology2024

Adenosine A2a Receptor Polymorphisms and Susceptibility to Anxiety Disorders.

Mohammad Keyvanloo Shahrestanaki, Haniyeh Karami, Hadi Lotfi, Milad Khorasani, Zeinab Babaei, Mohammad Salari Zare, Marzieh Kafami, Ilia Abrishami

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Iranian journal of child neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Involvement of Adenosine ABrain and behavior · 2026
    Article
  2. Epigenetic Mechanisms of Suicidal Behavior Formation: A Review.Medical journal of the Islamic Republic of Iran · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad Keyvanloo ShahrestanakiDepartment of Biochemistry and Nutrition, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Haniyeh KaramiDepartment of Biochemistry and Nutrition, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Hadi LotfiLeishmaniasis Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Milad KhorasaniDepartment of Biochemistry and Nutrition, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Zeinab BabaeiDepartment of Clinical Biochemistry and Biophysics, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Mohammad Salari ZareDepartment of Neurology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Marzieh KafamiDepartment of Physiology and Pharmacology, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Ilia AbrishamiDepartment of Biochemistry and Nutrition, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anxiety disorders (ADs) are a group of mental disorders characterized by feelings of tension, fear, and excessive worrying in the face of life experiences. Aberrant signaling of adenosine A2a receptor (ADORA2A) is believed to be involved in the pathogenesis of ADs. Polymorphisms in the ADORA2A gene were shown to be associated with some of the patterns presented by ADs. The results of these studies have been inconsistent, making it hard to draw definitive conclusions. Therefore, this study performed a systematic review to clarify the associations between ADORA2A gene polymorphisms and ADs susceptibility. PubMed/Medline, Web of Science, and Scopus database using appropriate keywords, then screened for separation of suitable studies based on inclusion/exclusion criteria. Collectively, rs5751876 (1976T>C or previously 1083C>T) and rs35060421 (2592C>Tins) polymorphisms of ADORA2A were associated with an increased susceptibility to ADs. Moreover, rs2298383 TT genotype may be the causal regulatory factor, and ADORA2A T/C (rs2298383/rs3761422) haplotypes have significant susceptibility to ADs development. Additional research is needed to further define the role of ADORA2A gene polymorphisms in the pathogenesis of ADs.

Indexed as

AdenosineAdenosine A2a ReceptorAnxiety DisordersGenetic Polymorphism

Identifiers

PMID39478950
PMCPMC11520271

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.