ArticleGenome biology2024
Winsorization greatly reduces false positives by popular differential expression methods when analyzing human population samples.
Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
- Public Perceptions of Gambling in the UK Armed Forces: Understanding Stigma Via a Vignette Experiment.Journal of gambling studies · 2026Trial
- Distinct gut microbiome profiles characterize obese and non-obese patients with atherosclerosis: a metagenomic analysis.Journal of translational medicine · 2026Article
- Advanced prediction of cardiovascular-kidney-metabolic syndrome using eight machine learning models and 24 composite indices.BMC cardiovascular disorders · 2026Article
- Nutritional-metabolic risk stratification for delirium in surgical critically ill patients: joint associations of the triglyceride-glucose index and stress hyperglycemia ratio.Frontiers in nutrition · 2026Article
- Climate indirectly modulates tree survival of spruce beetle attacks via effects on constitutive and induced secondary metabolites.Frontiers in plant science · 2026Article
- The Influence of Age on Notch1 and VEGF-A Responses During Exercise.Journal of aging research · 2026Article
- Development and external validation of a machine learning model for predicting in-hospital mortality in ICU patients with diabetic kidney disease: a study utilizing the MIMIC database and a Chinese cohort.Frontiers in endocrinology · 2026Article
- Association between stress hyperglycemia ratio and delirium risk in elderly surgical patients: a retrospective cohort study.BMC geriatrics · 2025Article
- Triglyceride-glucose index and postoperative delirium: a retrospective study exploring a lipid-related marker in neuropsychiatric risk stratification after gastric surgery.Lipids in health and disease · 2025Article
- Glycemic variability and postoperative mortality following cardiac surgery: evidence from a real-world ICU cohort.BMC cardiovascular disorders · 2025Observational
- Association between atherogenic index of plasma and sepsis in critically ill patients with ischemic stroke: a retrospective cohort study using propensity score and machine learning approaches.Lipids in health and disease · 2025Article
- The Mediating Role of Alexithymia in the Relationship between Maladaptive Object Relations Patterns and Depression.Iranian journal of psychiatry · 2025Article
- Association between triglyceride-glucose index trajectories and in-hospital mortality in sepsis: a cohort study based on the MIMIC-IV database.Lipids in health and disease · 2025Article
- Associations of lactate-to-hematocrit ratio with short- and long-term prognoses in critically ill patients with cirrhosis and sepsis: a retrospective cohort study.BMC infectious diseases · 2025Article
- Machine Learning for the Prediction of Acute Kidney Injury in Critically Ill Patients With Coronary Heart Disease: Algorithm Development and Validation.JMIR medical informatics · 2025Article
- Association between C-reactive protein-triglyceride glucose index and all-cause mortality and premature death: a joint analysis based on case data from the Central Hospital of Shaoyang and CHARLS database.Frontiers in medicine · 2025Article
- Non-linear association between serum levels of vitamins A and B12 and accelerated epigenetic aging.Frontiers in nutrition · 2025Article
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Abstract
A recent study found severely inflated type I error rates for DESeq2 and edgeR, two dominant tools used for differential expression analysis of RNA-seq data. Here, we show that by properly addressing the outliers in the RNA-Seq data using winsorization, the type I error rate of DESeq2 and edgeR can be substantially reduced, and the power is comparable to Wilcoxon rank-sum test for large datasets. Therefore, as an alternative to Wilcoxon rank-sum test, they may still be applied for differential expression analysis of large RNA-Seq datasets.
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