Evidence map›Paper›PMID 39478634›Full record

ArticleAdvanced healthcare materials2025

TLR Agonist Nano Immune Therapy Clears Peritoneal and Systemic Ovarian Cancer.

Ben Marwedel, Henning De May, Lauren Anderson, Lorél Y Medina, Ellie Kennedy, Erica Flores, John O'Rourke, Marian Olewine, Irina Lagutina, Lillian Fitzpatrick and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ben MarwedelDepartment of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM, 87131, USA.
Henning De MayDepartment of Obstetrics & Gynecology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, 87131, USA.
Lauren AndersonDepartment of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM, 87131, USA.
Lorél Y MedinaDepartment of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM, 87131, USA.
Ellie KennedyDepartment of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM, 87131, USA.
Erica FloresDepartment of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM, 87131, USA.
John O'RourkeBennuBio, 6610 Gulton Ct NE, Albuquerque, NM, 87109, USA.
Marian OlewineChemical and Biological Engineering, University of New Mexico, Albuquerque, NM, 87131, USA.
Irina LagutinaAnimal Models Shared Resource, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, 87131, USA.
Lillian FitzpatrickAnimal Models Shared Resource, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, 87131, USA.
Fred ShultzHuman Tissue Repository & Tissue Analysis, University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, 87131, USA.
Donna F KusewittHuman Tissue Repository & Tissue Analysis, University of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, 87131, USA.
Eric BarteeDepartment of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM, 87131, USA.
Sarah AdamsDepartment of Obstetrics & Gynecology, University of New Mexico Comprehensive Cancer Center, Albuquerque, NM, 87131, USA.
Achraf NoureddineChemical and Biological Engineering, University of New Mexico, Albuquerque, NM, 87131, USA.
Rita E SerdaDepartment of Internal Medicine, University of New Mexico Health Science Center, Albuquerque, NM, 87131, USA.ORCID 0000-0003-4640-6332

Funding

WOMEN'S CANCERS RESEARCH PROGRAMP30CA118100 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Yolanda Sanchez · 2005 to 2026
$57.1M
Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Samuel Joseph Endicott · 2017 to 2026
$24.9M
Impact of TNF on Oncolytic VirotherapyR01CA276134 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Eric Carter Bartee · 2023 to 2026
$1.7M
NCI NIH HHS P30 CA118100NCI NIH HHS R01 CA276134NIGMS NIH HHS P20 GM121176NIH HHS NCI P30 CA118100NIH HHS P20GM121176Oxnard Foundation
6 · The paper itself

Abstract

Intraperitoneal (IP) administration of immunogenic mesoporous silica nanoparticles (iMSN) in a mouse model of metastatic ovarian cancer promotes the development of tumor-specific CD8

Indexed as

ImmunotherapyNanoparticlesOvarian NeoplasmsPeritoneal NeoplasmsToll-Like ReceptorsAnimalsCD8-Positive T-LymphocytesCell Line, TumorFemaleHumansLipid AMiceMice, Inbred C57BLOligodeoxyribonucleotidesPolyethyleneimineSilicon DioxideCPG-oligonucleotideLipid Amonophosphoryl lipid AOligodeoxyribonucleotidesPolyethyleneimineSilicon DioxideToll-Like Receptorsintraperitoneal administrationmesoporous silica nanoparticleovarian cancerperitoneal metastasistoll‐like receptor agonist

Identifiers

PMID39478634
PMCPMC11912102

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.