ArticleNature2025
Progressive plasticity during colorectal cancer metastasis.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 123 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
123 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global research trends and hotspots of colorectal cancer organoids: a bibliometric insight and visualization analysis via multiple databases.Frontiers in oncology · 2026Pooled it
- Stemness in Colon Cancer.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Reframing cancer therapy through tumor plasticity.Nature cancer · 2026Review
- Cell plasticity in cancer and therapy resistance.Experimental & molecular medicine · 2026Review
- Identification of differential topologically associating domains from low sequencing depth and pseudobulk chromatin contact maps.Genome research · 2026Article
- Foundation model reveals the shared organization of transcription and topologically associating domains.Cell systems · 2026Article
- Integrated clinicogenomic analysis reveals the evolution and metastatic tropisms of advanced colorectal cancer.Cancer cell · 2026Article
- Article
- Article
- Oncofetal cell states: cell plasticity drives invasion in premetastatic colorectal tumors.Signal transduction and targeted therapy · 2026Article
- Exosome-delivered pepDCBLD2 promotes glucose metabolism to induce chemoresistance in colon cancer.Journal of translational medicine · 2026Article
- Article
- Lineage plasticity driven by GATA6 loss fuels colorectal cancer metastasis.Cell stem cell · 2026Article
- CellRank: consistent and data view agnostic fate mapping for single-cell genomics.Nature protocols · 2026Review
- Article
- Transcriptomic profiling identifies immunotherapy-responsive phenotypes in microsatellite-stable metastatic colorectal cancer.Oncogene · 2026Article
- Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in colorectal cancer.Cancer cell · 2026Article
- Microenvironment-Driven Reprogramming in Colorectal Cancer Liver Metastasis: Metabolic, Phenotypic, and Immune Adaptation.International journal of molecular sciences · 2026Review
- Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5Science advances · 2026Article
- KMT2D loss drives adeno-to-squamous transition and sensitizes TKI-resistant lung cancer to AURKA inhibition.Cell death and differentiation · 2026Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
- Erratum issued
- Update of
Authors and funding
39 authors.
Andrew Moorman *Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Elizabeth K Benitez *Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Francesco Cambuli *Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Qingwen JiangMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ahmed MahmoudMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Melissa LumishMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4173-5567
Saskia HartnerMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0009-0006-1030-1191
Sasha BalkaranMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-9991-6649
Jonathan BermeoMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-9553-9222
Simran AsawaMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-9015-254X
Canan FiratDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Asha SaxenaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-3410-4436
Fan WuDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-3960-320X
Anisha LuthraDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cassandra BurdziakComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yubin XieComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Valeria SgambatiMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kathleen LuckettMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yanyun LiDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zhifan YiDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ignas MasilionisComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Kevin SoaresDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-0406-017X
Emmanouil PappouDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8735-1852
Rona YaegerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7233-5454
T Peter KinghamDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
William JarnaginDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Philip B PatyDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7045-2112
Martin R WeiserDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-9577-7984
Linas MazutisComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5552-6427
Michael D'AngelicaDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jinru ShiaDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4351-2511
Julio Garcia-AguilarDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2451-0948
Tal NawyComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-3720-3699
Travis J HollmannDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4332-3291
Ronan ChalignéComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Francisco Sanchez-VegaDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Roshan SharmaComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Dana Pe'erComputational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. peerd@mskcc.org.ORCID http://orcid.org/0000-0002-9259-8817
Karuna GaneshMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ganeshk@mskcc.org.ORCID http://orcid.org/0000-0002-4948-1082
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MWeill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MThe Center for Tumor-Immune Systems Biology at MSKCCU54CA274492 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Christina S Leslie · 2022 to 2026
$16.3MTransition to Metastatic State: Lung Cancer, Pancreatic Cancer and Brain MetastasisU2CCA233284 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI IACOBUZIO-DONAHUE, CHRISTINE A · 2018 to 2022
$12.9MTumor-specific T cell state dynamics and heterogeneity in early tumorigenesisU54CA209975 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LESLIE, CHRISTINA S, RUDENSKY, ALEXANDER Y · 2016 to 2021
$11.8MWeill Cornell/Rockefeller/Sloan Kettering MST ProgramT32GM152349 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KATHARINE C HSU · 2024 to 2026
$6.6MMechanisms of Dynamic Transcriptional Reprogramming in Metastasis Stem CellsR37CA266185 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Karuna Ganesh · 2022 to 2026
$2.6MDeformation Corrected Image Guided Laparoscopic Liver SurgeryR01EB027498 · NIBIB · VANDERBILT UNIVERSITY · PI JARNAGIN, WILLIAM ROBERT, MIGA, MICHAEL IAN · 2019 to 2022
$2.5MInvestigating L1CAM-dependent stem cell regeneration in metastasisK08CA230213 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI GANESH, KARUNA · 2018 to 2022
$1.3MNCI NIH HHS K08 CA230213NCI NIH HHS P30 CA008748NCI NIH HHS R37 CA266185NCI NIH HHS U2C CA233284NCI NIH HHS U54 CA209975NCI NIH HHS U54 CA274492NIBIB NIH HHS R01 EB027498NIGMS NIH HHS T32 GM007739NIGMS NIH HHS T32 GM152349
Abstract
As cancers progress, they become increasingly aggressive-metastatic tumours are less responsive to first-line therapies than primary tumours, they acquire resistance to successive therapies and eventually cause death
Indexed as
Cell PlasticityColorectal NeoplasmsDisease ProgressionNeoplasm MetastasisCell DifferentiationCell LineageFemaleHomeodomain ProteinsHumansIntestinesMaleNeoplastic Stem CellsOrganoidsTumor MicroenvironmentTumor Suppressor ProteinsHomeodomain ProteinsTumor Suppressor Proteins
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.