ArticleNature2024
Engineered odorant receptors illuminate the basis of odour discrimination.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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Who cites it
21 citing papers in PubMed.
- Allosteric Gating Mechanism Regulates Odorant Selectivity and Antagonism in Odorant Receptors.bioRxiv : the preprint server for biology · 2026Article
- Decoding Smell from Receptor Structure.Research square · 2026Article
- A clinical and mechanistic study on traditional Chinese medicine herbs used in olfactory training.Chinese medicine · 2026Article
- Structural basis of the sweat odorant HMHA recognition by the human odorant receptor OR52E8.Communications biology · 2026Article
- A sensory-computational framework to decipher and predict binary aroma interactions: A case study of furaneol with five Co-odorants.Food chemistry: X · 2026Article
- Structural basis of odorant recognition by a mammalian class II odorant receptor.Science advances · 2026Article
- Elucidating odorant synergy in red wine: through olfactory receptor-based profiling.NPJ science of food · 2026Article
- Strategic advances for cryo-EM structural studies of small (<100 kDa) GPCRs.Communications biology · 2026Review
- Extra-nasal odorant receptors: molecular mechanisms and therapeutic implications.Frontiers in physiology · 2026Review
- Physiopathology of nasal and ecnomotopic olfactory receptors: focus on molecular pathways and potential pharmacological modulation.Frontiers in pharmacology · 2026Review
- Non-markovian electron tunneling in SARS-CoV-2 virus infection in structured environments.PloS one · 2026Article
- Article
- Probing the optimal architecture and molecular mechanism of insect odorant receptor heteromeric channels.Communications biology · 2025Article
- Chemosensory Receptors in Vertebrates: Structure and Computational Modeling Insights.International journal of molecular sciences · 2025Review
- Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer.Nature immunology · 2025Article
- Exploring LinearJournal of medicinal chemistry · 2025Article
- A covalent recognition strategy enables conspecific mate identification.bioRxiv : the preprint server for biology · 2025Article
- An odorant receptor for a key odor constituent of ambergris.Communications biology · 2025Article
- Design Principles From Natural Olfaction for Electronic Noses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Olfactory GPCRs through the lens of structural bioinformatics.Chemical senses · 2025Review
Corrections and comments
- Update of
Authors and funding
13 authors.
Claire A de March *Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA. claire.de-march@cnrs.fr.ORCID 0000-0001-6461-5547
Ning Ma *Department of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.ORCID 0000-0003-4653-7797
Christian B Billesbølle *Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8084-1552
Jeevan TewariDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.ORCID 0000-0001-6786-3917
Claudia Llinas Del TorrentDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6772-6856
Wijnand J C van der VeldenDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA.ORCID 0000-0003-0785-3762
Ichie OjiroDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Ikumi TakayamaDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Bryan FaustDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Linus LiDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-8302-7860
Nagarajan VaidehiDepartment of Computational and Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA, USA. NVaidehi@coh.org.ORCID 0000-0001-8100-8132
Aashish ManglikDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA. aashish.manglik@ucsf.edu.ORCID 0000-0002-7173-3741
Hiroaki MatsunamiDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA. hiroaki.matsunami@duke.edu.ORCID 0000-0002-8850-2608
Funding
The Stanford-SLAC CryoEM Center supplementU24GM129541 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH, HEDMAN, BRITT · 2018 to 2023
$54.8MEnhancing olfactory receptor expression for biochemical studies of odorant-receptor interactionsR01DC020353 · NIDCD · DUKE UNIVERSITY · PI Aashish Manglik, Hiroaki Matsunami · 2022 to 2026
$3.3MAcquisition of an electron microscope for high-resolution single particle cryo-EMS10OD021741 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2016 to 2016
$2.0MGlacios™ Cryo Transmission Electron Microscope with 200 kV XFEG opticsS10OD026881 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2019 to 2019
$1.8MLinux cluster for near atomic resolution single particle cryo-EMS10OD020054 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2015 to 2015
$456kUnderstanding of G protein-coupled odorant receptors functionK99DC018333 · NIDCD · DUKE UNIVERSITY · PI DE MARCH, CLAIRE A. · 2020 to 2021
$172kNIDCD NIH HHS K99 DC018333NIDCD NIH HHS R01 DC020353NIGMS NIH HHS U24 GM129541NIH HHS S10 OD020054NIH HHS S10 OD021741NIH HHS S10 OD026881
Abstract
How the olfactory system detects and distinguishes odorants with diverse physicochemical properties and molecular configurations remains poorly understood. Vertebrate animals perceive odours through G protein-coupled odorant receptors (ORs)
Indexed as
OdorantsOlfactory PerceptionProtein EngineeringReceptors, OdorantCryoelectron MicroscopyDiscrimination, PsychologicalHumansLigandsModels, MolecularNeoplasm ProteinsProtein BindingLigandsNeoplasm ProteinsOR51E2 protein, humanReceptors, Odorant
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.