ArticleNature2024
Tumour evolution and microenvironment interactions in 2D and 3D space.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
146 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Modeling metastasis and predicting drug response with malignant effusion-derived organoids: a systematic review and quantitative assessment.Journal of translational medicine · 2026Pooled it
- Deep representation learning for temporal inference in cancer omics: a systematic literature review.Briefings in bioinformatics · 2026Pooled it
- Stress-specific 14-3-3-client modules in digestive cancers: an evidence-graded review of adaptive survival and therapy resistance.Cancer biology & therapy · 2026Review
- Clonal heterogeneity in human pancreatic ductal adenocarcinoma and its impact on tumor progression.Nature genetics · 2026Article
- Unlocking the full potential of spatial omics in plants: practical challenges, solutions, and a path forward.The Plant cell · 2026Review
- A NIR-II AIEgen with superior fluorescence and photothermal performance for precision theranostics.Science advances · 2026Article
- Review
- 3D multi-omics tumour atlases: from technology to biology and clinical translation.Nature reviews. Cancer · 2026Review
- Genomic instability, postoperative recurrence and therapeutic vulnerabilities in resectable non‑small cell lung cancer (Review).Oncology reports · 2026Review
- Unveiling the role of spatial transcriptomics in the analysis of the tumor immune microenvironment (Review).International journal of molecular medicine · 2026Review
- The Next Frontier in Quantitative Co-Clinical Imaging to Advance Functional Precision Oncology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Heterogeneity in cancer: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Pan-tumor spatial transcriptomics reveals conserved properties of tumor organization.Cell reports. Medicine · 2026Article
- Deep Learning-Assisted Prioritization of Candidate Drug Targets in Tumors Using Spatial Multi-Omics.Biology · 2026Review
- Benchmarking copy number alteration inference methods for spatial transcriptomics.Nature communications · 2026Article
- Cytokine fusion proteins for solid tumor therapy: mechanistic insights and clinical advances.Journal of hematology & oncology · 2026Review
- A multiperspective evaluation framework of spatial transcriptomics clustering methods.NAR genomics and bioinformatics · 2026Article
- Intratumoral Mycobacterium abscessus promotes cytidine deaminase mutagenesis in non-small cell lung cancer.Signal transduction and targeted therapy · 2026Article
- Towards universal deconvolution of tissue-level multiomics for translational medicine.Clinical and translational medicine · 2026Article
- Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate.Cancer discovery · 2026Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors.
Chia-Kuei Mo *Department of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0009-0005-7056-0841
Jingxian Liu *Department of Medicine, Washington University in St Louis, St Louis, MO, USA.
Siqi ChenDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Erik StorrsDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Andre Luiz N Targino da CostaDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Andrew HoustonDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Michael C WendlDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Reyka G JayasingheDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-2368-4890
Michael D IglesiaDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-0841-2144
Cong MaDepartment of Computer Science, Princeton University, Princeton, NJ, USA.
John M HerndonDepartment of Surgery, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-8378-9654
Austin N Southard-SmithDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-0022-6897
Xinhao LiuDepartment of Computer Science, Princeton University, Princeton, NJ, USA.
Jacqueline MuddDepartment of Surgery, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0001-7618-8765
Alla KarpovaDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-0467-0215
Andrew ShinkleDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
S Peter GoedegebuureDepartment of Surgery, Washington University in St Louis, St Louis, MO, USA.
Abdurrahman Taha Mousa Ali AbdelzaherDepartment of Surgery, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-0721-4506
Peng BoDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Lauren FulghumDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0009-0007-9824-2604
Samantha LivingstonDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Metin BalabanDepartment of Computer Science, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-6947-5915
Angela HillDepartment of Surgery, Washington University in St Louis, St Louis, MO, USA.
Joseph E IppolitoDepartment of Radiology, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-1913-5573
Vesteinn ThorssonInstitute for Systems Biology, Seattle, WA, USA.
Jason M HeldSiteman Cancer Center, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0001-8024-2736
Ian S HagemannDepartment of Pathology and Immunology, Washington University in St Louis, St Louis, MO, USA.
Eric H KimDivision of Urological Surgery, Department of Surgery, Washington University, St Louis, MO, USA.ORCID 0000-0002-0284-8342
Peter O BayguinovDepartment of Neuroscience, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-5365-7490
Albert H KimSiteman Cancer Center, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-1751-8493
Mary M MullenDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University, St Louis, MO, USA.
Kooresh I ShoghiSiteman Cancer Center, Washington University in St Louis, St Louis, MO, USA.
Tao JuDepartment of Computer Science and Engineering, Washington University in St Louis, St Louis, MO, USA.
Melissa A ReimersDivision of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA.
Cody WeimholtDepartment of Pathology and Immunology, Washington University in St Louis, St Louis, MO, USA.
Liang-I KangDepartment of Pathology and Immunology, Washington University in St Louis, St Louis, MO, USA.
Sidharth V PuramSiteman Cancer Center, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-3543-889X
Deborah J VeisDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0001-7101-5582
Russell PachynskiDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.
Katherine C FuhDepartment of Obstetrics and Gynecology, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-7693-2694
Milan G ChhedaDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0001-8282-9098
William E GillandersDepartment of Surgery, Washington University in St Louis, St Louis, MO, USA. gillandersw@wustl.edu.ORCID 0000-0002-0465-3071
Ryan C FieldsDepartment of Surgery, Washington University in St Louis, St Louis, MO, USA. rcfields@wustl.edu.ORCID 0000-0001-6176-8943
Benjamin J RaphaelDepartment of Computer Science, Princeton University, Princeton, NJ, USA. braphael@princeton.edu.ORCID 0000-0003-1274-048X
Feng ChenDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA. fchen@wustl.edu.ORCID 0000-0002-2307-7954
Li DingDepartment of Medicine, Washington University in St Louis, St Louis, MO, USA. lding@wustl.edu.ORCID 0000-0003-1517-2975
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0MWashington University Paul Calabresi K12 Career Development Award for Clinical OncologyK12CA167540 · NCI · WASHINGTON UNIVERSITY · PI John F. Dipersio, Ramaswamy Govindan · 2012 to 2026
$11.7MWashington University SPORE in Pancreatic CancerP50CA272213 · NCI · WASHINGTON UNIVERSITY · PI David G DeNardo, WILLIAM G HAWKINS · 2023 to 2026
$10.7MWASHINGTON UNIVERSITY HUMAN TUMOR ATLAS RESEARCH CENTERU2CCA233303 · NCI · WASHINGTON UNIVERSITY · PI FIELDS, RYAN C · 2018 to 2023
$9.7MWU-SN-TMC Data Analysis CoreU54AG075934 · NIA · WASHINGTON UNIVERSITY · PI FENG CHEN, Li Ding · 2021 to 2026
$8.0MWASHINGTON UNIVERSITY CO-CLINICAL IMAGING RESEARCH RESOURCEU24CA209837 · NCI · WASHINGTON UNIVERSITY · PI Li Ding, Shunqiang Li · 2017 to 2026
$6.3MComprehensive and Robust Tools for Analysis of Tumor Heterogeneity and EvolutionU24CA248453 · NCI · PRINCETON UNIVERSITY · PI Benjamin Raphael · 2020 to 2026
$4.7MProteogenomic Data Analysis for Cancer Systems Biology and Clinical TranslationU24CA210972 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DING, LI, FENYO, DAVID · 2016 to 2020
$3.3MFFNP-PET as a predictive biomarker of response to endocrine therapy approaches in advanced breast cancerR01CA273194 · NCI · WASHINGTON UNIVERSITY · PI DEHDASHTI, FARROKH, MA, CYNTHIA X · 2022 to 2025
$3.1MImpact of cancer predisposition on oncogenic process, microenvironment, and treatmentR01CA260112 · NCI · WASHINGTON UNIVERSITY · PI FENG CHEN, Li Ding · 2022 to 2026
$2.4MPathogenic Variant Discovery Across a Broad Spectrum of Human DiseasesR01HG009711 · NHGRI · WASHINGTON UNIVERSITY · PI CHEN, FENG, DING, LI · 2017 to 2020
$2.2MLeveraging Zika virus and the immune system to treat glioblastomaR01NS117149 · NINDS · WASHINGTON UNIVERSITY · PI CHHEDA, MILAN GIRISH · 2021 to 2025
$2.1MNCI NIH HHS K12 CA167540NCI NIH HHS P30 CA091842NCI NIH HHS P50 CA272213NCI NIH HHS R01 CA260112NCI NIH HHS R01 CA273194NCI NIH HHS U24 CA209837NCI NIH HHS U24 CA210972NCI NIH HHS U24 CA248453NCI NIH HHS U24 CA264027NCI NIH HHS U2C CA233303NHGRI NIH HHS R01 HG009711NIA NIH HHS U54 AG075934NINDS NIH HHS R01 NS107833NINDS NIH HHS R01 NS117149
Abstract
To study the spatial interactions among cancer and non-cancer cells
Indexed as
NeoplasmsTumor MicroenvironmentAntigen PresentationClone CellsCohort StudiesDeep LearningDNA Copy Number VariationsGene Expression ProfilingHumansMacrophagesMutationStromal CellsT-LymphocytesTranscriptomeUnsupervised Machine Learning
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Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.