ArticleNature2024
Temporal recording of mammalian development and precancer.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- 3D multi-omics tumour atlases: from technology to biology and clinical translation.Nature reviews. Cancer · 2026Review
- The development of single-cell lineage tracing technology and its application in immunotherapy.Molecular therapy. Advances · 2026Review
- Disruption of cellular timekeeping in cancer: links between circadian clocks, metabolism, and tumor progression.Molecular biology reports · 2026Review
- Genomic repeats for single-cell molecular recording.bioRxiv : the preprint server for biology · 2026Article
- BASELINE: a CRISPR base editing platform for mammalian-scale single-cell lineage tracing.Nucleic acids research · 2026Article
- Trimodal, uncertainty-guided whole-slide framework for genome-scale spatial expression and image-only virtual perturbation in cancer cohorts.Genome medicine · 2026Article
- Lineage tracing from cellular heritage to disease destiny.Nature genetics · 2026Review
- Beyond the chaos: How architecture structures tumour biology.The FEBS journal · 2026Review
- Mapping breast cancer lineage in radiation and immunotherapy using the REMAP mouse.bioRxiv : the preprint server for biology · 2026Article
- Precancerous microenvironment: A signalling perspective.Current opinion in cell biology · 2026Review
- Strength through diversity: how cancers thrive when clones cooperate.Molecular oncology · 2026Review
- Article
- Review
- Signaling pathways and targeted interventions for precancers.Signal transduction and targeted therapy · 2026Review
- Article
- Precision Oncology: Current Landscape, Emerging Trends, Challenges, and Future Perspectives.Cells · 2025Review
- Polyclonal origins of human premalignant colorectal lesions.bioRxiv : the preprint server for biology · 2025Article
- Opposing lineage specifiers induce a protumor hybrid identity state in lung adenocarcinoma.Genes & development · 2025Article
- Stem Cell and Synthetic Embryo Models: Advances, Applications, and Ethical Considerations.Stem cell reviews and reports · 2025Review
- Molecular circuits for genomic recording of cellular events.Trends in genetics : TIG · 2025Review
Corrections and comments
- Update of
Authors and funding
26 authors.
Mirazul IslamEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-4959-739X
Yilin YangEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0009-0000-9869-4044
Alan J SimmonsEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-3412-5819
Vishal M ShahEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Krushna Pavan MusaleDepartment of Computer Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, India.ORCID 0000-0002-7856-8224
Yanwen XuEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Naila TasneemEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0009-0009-6450-9475
Zhengyi ChenEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-4774-945X
Linh T TrinhDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Paola MolinaDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Marisol A Ramirez-SolanoDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Iannish D SadienCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0002-3367-1252
Jinzhuang DouDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Andrea RolongEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Ken ChenDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-4013-5279
Mark A MagnusonDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-8824-6499
Jeffrey C RathmellVanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-4106-3396
Ian G MacaraEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-8546-5357
Douglas J WintonCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6067-7927
Qi LiuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Hamim ZafarDepartment of Computer Science and Engineering, Indian Institute of Technology Kanpur, Kanpur, India.ORCID 0000-0002-1617-2806
Reza KalhorDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-5558-7545
George M ChurchDepartment of Genetics, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6232-9969
Martha J ShrubsoleDepartment of Medicine, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Robert J CoffeyEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA. robert.coffey@vumc.org.ORCID 0000-0002-2180-3844
Ken S LauEpithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.ORCID 0000-0001-8438-0319
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MVanderbilt-Ingram Cancer Center SPORE in Gastrointestinal CancerP50CA236733 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STEPHEN W. FESIK · 2019 to 2026
$19.6MMolecular, Cellular and Tissue Characterization UnitU2CCA233291 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J., SHRUBSOLE, MARTHA J. · 2018 to 2023
$12.2MShaping the Microenvironment by DPEP1 Facilitates Adenoma ProgressionU54CA274367 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Bhuminder Singh · 2022 to 2026
$9.7MIntegrated approach to study early and late events in colonic neoplasia: mouse to manR35CA197570 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2017 to 2026
$9.4MIntegrated Biological Systems Training in OncologyT32CA119925 · NCI · VANDERBILT UNIVERSITY · PI Vivian Gama, William Patrick Tansey · 2008 to 2026
$7.6MTuft cell heterogeneity in function, lineage, and structure in ileal inflammatory diseaseR01DK103831 · NIDDK · VANDERBILT UNIVERSITY · PI LAU, KEN S · 2016 to 2024
$4.4MMetabolic Barriers to T Cell Activation in Clear Cell Renal Cell CarcinomaR01CA217987 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey C Rathmell · 2018 to 2026
$4.3MMapping the dynamics of mouse neurogenesis in autism models using high-resolution genomic barcoding technologiesR01HG012357 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI KALHOR, REZA · 2022 to 2025
$2.1MDiet, Genetics, Epigenetics and Colorectal Adenoma Risk.K07CA122451 · NCI · VANDERBILT UNIVERSITY · PI SHRUBSOLE, MARTHA J. · 2007 to 2011
$655kNCATS NIH HHS UL1 TR000445NCI NIH HHS K07 CA122451NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA236733NCI NIH HHS R01 CA217987NCI NIH HHS R35 CA197570NCI NIH HHS T32 CA119925NCI NIH HHS U2C CA233291NCI NIH HHS U54 CA274367NHGRI NIH HHS R01 HG012357NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK103831
Abstract
Temporal ordering of cellular events offers fundamental insights into biological phenomena. Although this is traditionally achieved through continuous direct observations
Indexed as
Cell LineageEmbryonic DevelopmentPrecancerous ConditionsSingle-Cell AnalysisAdenomaAnimalsCarcinogenesisClone CellsColonic NeoplasmsCRISPR-Cas SystemsFemaleHumansMaleMiceMultiomicsOrgan Specificity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.