Evidence map›Paper›PMID 39478152›Full record

ArticleEMBO molecular medicine2024

Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas.

Jing Chen, Michal Sobecki, Ewelina Krzywinska, Kevin Thierry, Mélissa Masmoudi, Shunmugam Nagarajan, Zheng Fan, Jingyi He, Irina Ferapontova, Eric Nelius and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jing ChenUniversity of Zurich, Institute of Anatomy, Winterthurerstrasse 190, CH - 8057, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-1835-2373
Michal SobeckiUniversity of Zurich, Institute of Anatomy, Winterthurerstrasse 190, CH - 8057, Zurich, Switzerland.
Ewelina KrzywinskaUniversity of Zurich, Institute of Anatomy, Winterthurerstrasse 190, CH - 8057, Zurich, Switzerland.
Kevin ThierryCancer Research Center of Lyon, UMR INSERM 1052, CNRS, 5286, Lyon, France.ORCID http://orcid.org/0000-0003-0123-3124
Mélissa MasmoudiCancer Research Center of Lyon, UMR INSERM 1052, CNRS, 5286, Lyon, France.ORCID http://orcid.org/0009-0006-2426-2621
Shunmugam NagarajanUniversity of Zurich, Institute of Anatomy, Winterthurerstrasse 190, CH - 8057, Zurich, Switzerland.
Zheng FanUniversity of Zurich, Institute of Anatomy, Winterthurerstrasse 190, CH - 8057, Zurich, Switzerland.
Jingyi HeUniversity of Zurich, Institute of Anatomy, Winterthurerstrasse 190, CH - 8057, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-3640-3093
Irina FerapontovaUniversity of Zurich, Institute of Anatomy, Winterthurerstrasse 190, CH - 8057, Zurich, Switzerland.
Eric NeliusUniversity of Zurich, Institute of Anatomy, Winterthurerstrasse 190, CH - 8057, Zurich, Switzerland.
Frauke SeehusenLaboratory for Animal Model Pathology (LAMP), Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, 8057, Zurich, Switzerland.
Dagmar GotthardtInstitute of Pharmacology and Toxicology, University of Veterinary Medicine, 1210, Vienna, Austria.ORCID http://orcid.org/0000-0002-8416-1236
Norihiko TakedaDepartment of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Lukas SommerUniversity of Zurich, Institute of Anatomy, Winterthurerstrasse 190, CH - 8057, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-1143-7908
Veronika SexlUniversity of Innsbruck, Innrain 52, 6020, Innsbruck, Austria.
Christian MünzViral Immunobiology, Institute of Experimental Immunology, University of Zürich, 8057, Zürich, Switzerland.ORCID http://orcid.org/0000-0001-6419-1940
David DeNardoDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Ana HenninoCancer Research Center of Lyon, UMR INSERM 1052, CNRS, 5286, Lyon, France.ORCID http://orcid.org/0000-0002-2619-8559
Christian StockmannUniversity of Zurich, Institute of Anatomy, Winterthurerstrasse 190, CH - 8057, Zurich, Switzerland. christian.stockmann@anatomy.uzh.ch.ORCID http://orcid.org/0000-0002-9726-6838

Funding

Japan Agency for Medical Research and Development (AMED) JP23gm6510023SNF | Swiss National Centre of Competence in Research Kidney Control of Homeostasis (NCCR Kidney.CH) N-403-06-26 HCPSwiss Cancer League KFS-4398-02-2018Swiss Cancer League KFS-5402-08-2021Swiss National Science Fundation 310030_179235University of Zurich Forschungskredit UZH Postdoc 2019
6 · The paper itself

Abstract

A hallmark feature of pancreatic ductal adenocarcinoma (PDAC) is massive intratumoral fibrosis, designated as desmoplasia. Desmoplasia is characterized by the expansion of cancer-associated fibroblasts (CAFs) and a massive increase in extracellular matrix (ECM). During fibrogenesis, distinct genes become reactivated specifically in fibroblasts, e.g., the disintegrin metalloprotease, ADAM12. Previous studies have shown that immunotherapeutic ablation of ADAM12

Indexed as

ADAM12 ProteinCancer VaccinesPancreatic NeoplasmsAdenocarcinomaAnimalsCancer-Associated FibroblastsCarcinoma, Pancreatic DuctalCD8-Positive T-LymphocytesDisease Models, AnimalFibrosisHumansMiceMice, Inbred C57BLVaccinationADAM12 ProteinAdam12 protein, mouseCancer VaccinesCancer-Associated FibroblastsImmunotherapyPancreatic AdenocarcinomaVaccination

Identifiers

PMID39478152
PMCPMC11628623

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.