Evidence map›Paper›PMID 39478136›Full record

ArticleScientific reports2024

Blood culture-negative endocarditis caused by Bartonella quintana in Iran.

Masoud Azimzadeh, Mohammad Yousef Alikhani, Alireza Sazmand, Kianoush Saberi, Zohreh Farahani, Monireh Kamali, Mahdi Haddadzadeh, Gholamreza Safarpoor, Alireza Nourian, Younes Mohammadi and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Molecular investigation ofNew microbes and new infections · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Masoud AzimzadehDepartment of Microbiology, Hamadan University of Medical Sciences, Hamadan, Iran.ORCID 0000-0003-1166-872X
Mohammad Yousef AlikhaniDepartment of Microbiology, Hamadan University of Medical Sciences, Hamadan, Iran. alikhani43@yahoo.com.ORCID 0000-0003-4577-4029
Alireza SazmandDepartment of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, 6517658978, Iran. alireza.sazmand@basu.ac.ir.ORCID 0000-0002-8450-2993
Kianoush SaberiDepartment of Anesthesia, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-4292-2252
Zohreh FarahaniDepartment of Nursery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0009-0002-6659-1141
Monireh KamaliDepartment of Infectious Diseases, Shaheed Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-8708-845X
Mahdi HaddadzadehDepartment of Cardiac Surgery, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, 8915887856, Iran.
Gholamreza SafarpoorDepartment of Cardiovascular Surgery, School of Medicine, Farshchian Cardiovascular Subspecialty Medical Center, Hamadan University of Medical Sciences, Hamadan, Iran.ORCID 0000-0002-2050-7146
Alireza NourianDepartment of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, 6517658978, Iran.ORCID 0000-0002-3567-8677
Younes MohammadiDepartment of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.ORCID 0000-0001-7521-4909
Farzad BeikpourDepartment of Pediatrics, School of Medicine, Washington University, St. Louis, MO, 63110, USA.ORCID 0000-0001-9661-3917
Mehrdad SalehiDepartment of Cardiovascular and Transplantation Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-7836-9655
Grazia GrecoDepartment of Veterinary Medicine, University of Bari "Aldo Moro", Valenzano, 70010, Bari, Italy.ORCID 0000-0002-4338-6746
Bruno ChomelDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, USA.ORCID 0000-0001-9600-0416

Funding

Hamadan University of Medical Sciences 9812209686
6 · The paper itself

Abstract

Blood culture-negative endocarditis (BCNE) is a challenging disease because of the significant impact of delayed diagnosis on patients. In this study, excised heart valves and blood serum samples were collected from 50 BCNE patients in two central hospitals in Tehran, Iran. Sera were tested by IFA for the presence of IgG and IgM antibodies against Bartonella quintana and B. henselae. Genomic DNA extracted from the heart valves was examined for Bartonella-specific ssrA gene in a probe-based method real-time PCR assay. Any positive sample was Sanger sequenced. IgG titer higher than 1024 was observed in only one patient and all 50 patients tested negative for Bartonella IgM. By real-time PCR, the ssrA gene was detected in the valve of one patient which was further confirmed to be B. quintana. Bartonella-like structures were observed in transmission electron microscopy images of that patient. We present for the first time the involvement of Bartonella in BCNE in Iran. Future research on at-risk populations, as well as domestic and wild mammals as potential reservoirs, is recommended.

Indexed as

Bartonella quintanaAdultAgedAntibodies, BacterialBlood CultureEndocarditis, BacterialFemaleHumansImmunoglobulin GImmunoglobulin MIranMaleMiddle AgedTrench FeverYoung AdultAntibodies, BacterialImmunoglobulin GImmunoglobulin MBartonella quintanaBCNEIFAInfective endocarditisProbeReal-time PCRTEM

Identifiers

PMID39478136
PMCPMC11525736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.