Evidence map›Paper›PMID 39477917›Full record

ArticleNature communications2024

Selective monodeuteration enabled by bisphosphonium catalyzed ring opening processes.

Yuanli Xu, Wenlong Chen, Ruihua Pu, Jia Ding, Qing An, Yi Yang, Weimin Liu, Zhiwei Zuo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuanli Xu *Innovation Center for Chenguang High Performance Fluorine Material, Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education, Sichuan University of Science and Engineering, 643000, Zigong, China.
Wenlong Chen *State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032, Shanghai, China.
Ruihua PuSchool of Physical Science and Technology, ShanghaiTech University, 201210, Shanghai, China.
Jia DingState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032, Shanghai, China.ORCID http://orcid.org/0000-0001-7328-011X
Qing AnState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032, Shanghai, China.
Yi YangInnovation Center for Chenguang High Performance Fluorine Material, Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education, Sichuan University of Science and Engineering, 643000, Zigong, China. yangyiyoung@163.com.ORCID http://orcid.org/0000-0001-6057-3378
Weimin LiuSchool of Physical Science and Technology, ShanghaiTech University, 201210, Shanghai, China. liuwm@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0002-9359-1465
Zhiwei ZuoState Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032, Shanghai, China. zuozhw@sioc.ac.cn.ORCID http://orcid.org/0000-0002-3361-3220

Funding

National Natural Science Foundation of China (National Science Foundation of China) 21971163National Natural Science Foundation of China (National Science Foundation of China) 22125111
6 · The paper itself

Abstract

The selective incorporation of a deuterium atom into small molecules with high selectivity is highly valuable for medical and chemical research. Unfortunately, this remains challenging due to the complete deuteration caused by commonly used hydrogen isotope exchange strategies. We report the development of a photocatalytic selective monodeuteration protocol utilizing C-C bond as the unconventional functional handle. The synergistic combination of radical-mediated C-C bond scission and deuterium atom transfer processes enables the effective constructions of benzylic CDH moieties with high selectivity for monodeuteration. The combinational use of a bisphosphonium photocatalyst, thiol catalyst, and CH

Identifiers

PMID39477917
PMCPMC11526102

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.