ArticlePharmacoepidemiology and drug safety2024
A Validated Algorithm to Identify Hepatic Decompensation in the Veterans Health Administration Electronic Health Record System.
Lamia Y Haque, Janet P Tate, Michael Chew, Ellen C Caniglia, Tamar H Taddei, Vincent Lo Re
Abstract readValidation Study
In one paragraphArticle in Pharmacoepidemiology and drug safety, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Lamia Y HaqueSection of Digestive Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-6650-0978 Janet P TateVeterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA.
Michael ChewSection of Digestive Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Ellen C CanigliaDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Tamar H TaddeiSection of Digestive Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Vincent Lo ReDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-7955-0600 Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MAlcohol Associated Outcomes Among HIV+/- Aging VeteransU10AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2006 to 2010
$12.7MAlcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7MYale Drug use, Addiction and HIV Research Scholars (DAHRS)K12DA033312 · NIDA · YALE UNIVERSITY · PI Gail D'Onofrio, Patrick O'Connor · 2013 to 2026
$7.2MSex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5MIntegrated Stepped Care for Unhealthy Alcohol Use in HIVU01AA020795 · NIAAA · YALE UNIVERSITY · PI FIELLIN, DAVID · 2011 to 2020
$5.2MConsortium to improve Outcomes in HIV/AIDS, Alcohol, Aging & multi-Substance useU01AA020799 · NIAAA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BRAITHWAITE, RONALD SCOTT · 2011 to 2020
$2.1MIntegrating Treatments for Alcohol Use Disorder into Hepatology ClinicsK23AA031334 · NIAAA · YALE UNIVERSITY · PI Lamia Haque · 2023 to 2026
$774kCHAART Cooperative AgreementCOMpAAAS/Veterans Aging Cohort StudyNCATS NIH HHS UL1 TR001863NIAAA NIH HHS K23 AA031334NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U01-AA020790NIAAA NIH HHS U01 AA020795NIAAA NIH HHS U01-AA020795NIAAA NIH HHS U01 AA020799NIAAA NIH HHS U01-AA020799NIAAA NIH HHS U10 AA013566NIAAA NIH HHS U24 AA020794NIAAA NIH HHS U24-AA020794NIDA NIH HHS K12 DA033312NIH HHSYale Drug Use, Addiction, and HIV Research Scholars Program K12DA033312
6 · The paper itselfAbstract
purposeAccurate identification of hepatic decompensation is essential for pharmacoepidemiologic research among patients with chronic liver disease.
methodsAn algorithm using ≥ 1 inpatient or ≥ 2 outpatient International Classification of Diseases, 10th revision (ICD-10) codes for hepatic decompensation was developed in Veterans Health Administration data from October 2015 through July 2019. Medical records were reviewed by hepatologists to confirm cases. The positive predictive value (PPV) of the coding algorithm for confirmed hepatic decompensation was calculated.
resultsHepatic decompensation was confirmed in 149/185 records meeting the algorithm (PPV 81%; 95% CI, 70%, 90%). The most common hepatic decompensation diagnosis was ascites. Only 56% of confirmed cases had an accompanying diagnosis code for cirrhosis.
conclusionsOur ICD-10-based coding algorithm identified hepatic decompensation with high PPV in Veterans Health Administration data.
Indexed as
AlgorithmsElectronic Health RecordsInternational Classification of DiseasesPharmacoepidemiologyUnited States Department of Veterans AffairsAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsUnited StatesVeterans Healthepidemiological methodshepatic decompensationliver cirrhosisvalidation
Identifiers
PMID39477692
PMCPMC11631147
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