Evidence map›Paper›PMID 39477499›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted

Anthony J Young, Austin R Pantel, Mahsa Kiani, Robert K Doot, Sina Bagheri, Daniel A Pryma, Michael D Farwell, Shihong Li, Hsiaoju Lee, Erin K Schubert and 10 more

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. The wings of progress: technological and radiopharmaceutical innovations in nuclear medicine.European journal of nuclear medicine and molecular imaging · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Anthony J YoungDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Austin R PantelDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Mahsa KianiDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Robert K DootDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Sina BagheriDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Daniel A PrymaDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Michael D FarwellDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Shihong LiDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Hsiaoju LeeDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Erin K SchubertDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Anthony SecretoDepartment of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Samantha P ZuckermanDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Anupma NayakDepartment of Pathology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Hoon ChoiDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Sean CarlinInvicro LLC, Needham, Massachusetts; and.
Angela DeMicheleDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
David A MankoffDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Rong ZhouDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Robert H MachDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Elizabeth S McDonaldDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; elizabeth.mcdonald@pennmedicine.upenn.edu.

Funding

Breast Cancer PARP PET Imaging AIP to Support FDA Approval & CommercializationR01CA258717 · NCI · UNIVERSITY OF PENNSYLVANIA · PI LIN, LILIE LEMING, MANKOFF, DAVID A. · 2021 to 2025
$2.9M
Tuning PARP-1 retention and release on DNA breaksR01CA259037 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Ben E. Black, John M Pascal · 2022 to 2026
$2.9M
Developing PARP-1 PET with companion tissue assay as a precision tool to guide PARPi therapyR37CA277541 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth McDonald · 2024 to 2026
$1.6M
NCI NIH HHS R01 CA258717NCI NIH HHS R01 CA259037NCI NIH HHS R37 CA277541
6 · The paper itself

Abstract

The poly(adenosine diphosphate-ribose) polymerase inhibitors (PARPi) have demonstrated efficacy in ovarian, breast, and prostate cancers, but current biomarkers do not consistently predict clinical benefit.

Indexed as

Breast NeoplasmsPoly (ADP-Ribose) Polymerase-1Positron-Emission TomographyAdultAgedAnimalsFemaleFluorine RadioisotopesHumansKineticsMiceMiddle AgedPoly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) PolymerasesRadiopharmaceuticalsTissue DistributionFluorine-18Fluorine RadioisotopesPARP1 protein, humanPoly (ADP-Ribose) Polymerase-1Poly(ADP-ribose) Polymerase InhibitorsPoly(ADP-ribose) PolymerasesRadiopharmaceuticals18F-fluorthanatracebreast cancerPARP-1radiotracer tissue pharmacokinetics

Identifiers

PMID39477499
PMCPMC11619586

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.