Evidence map›Paper›PMID 39477431›Full record

ArticleIn vivo (Athens, Greece)

The Effect of Dexmedetomidine and Levobupivacaine in an Experimental Ischemia Reperfusion Model.

Turna Halil Ibrahim, Kesici Sevgi, Oba Sibel, Cinar Ayse Surhan, Karatepe Kaan, Bozali Kubra, Kamali Gulcin, Guler Eray Metin, Sancak Demirci Nur Betul, Kesici Ugur

Abstract read
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In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Turna Halil IbrahimDepartment of Anesthesia and Reanimation, Health Science University, Hamidiye Etfal, Training, and Research Hospital, Istanbul, Turkey.
Kesici SevgiDepartment of Anesthesia and Reanimation, Health Science University, Hamidiye Etfal, Training, and Research Hospital, Istanbul, Turkey; md.kesici@mynet.com.
Oba SibelDepartment of Anesthesia and Reanimation, Health Science University, Hamidiye Etfal, Training, and Research Hospital, Istanbul, Turkey.
Cinar Ayse SurhanDepartment of Anesthesia and Reanimation, Health Science University, Hamidiye Etfal, Training, and Research Hospital, Istanbul, Turkey.
Karatepe KaanDepartment of General Surgery, Health Science University, Sultan 2. Abdülhamid Han, Training, and Research Hospital, Istanbul, Turkey.
Bozali KubraDepartment of Medical Biochemistry, University of Health Sciences, Haydarpasa Numune, Training and Research Hospital, Istanbul, Turkey.
Kamali GulcinDepartment of Pathology, Health Science University, Prof. Dr. Cemil Tascioglu, Training, and Research Hospital, Istanbul, Turkey.
Guler Eray MetinDepartment of Medical Biochemistry, University of Health Sciences, Haydarpasa Numune, Training and Research Hospital, Istanbul, Turkey.
Sancak Demirci Nur BetulDepartment of Anesthesia and Reanimation, Health Science University, Hamidiye Etfal, Training, and Research Hospital, Istanbul, Turkey.
Kesici UgurDepartment of General Surgery, Health Science University, Prof. Dr. Cemil Tascioglu, Training, and Research Hospital, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimAlthough it has been reported that different molecules are effective in preventing ischemia-reperfusion (I/R) injury, the most effective treatment is still unknown. MATERIALS AND

methodsThe rats were divided into four groups of eight rats each. Group C: 1 ml intraperitoneal (IP) isotonic + laparotomy + IP 2 ml isotonic +I/R. Group D: 100 μg kg

resultsGroup D mean blood TAS levels were found to be statistically significantly higher than those in Group C and Group L (p=0.037, p=0.048 respectively). Group DL oxidative stress index (OSI) value was found to be statistically significantly lower than that of Group C (p=0.010).

conclusionBoth dexmedetomidine and levobupivacaine demonstrated protective effects in I/R injury. When used in combination, the effects of these treatments were further enhanced, reaching statistical significance. As our literature review found no studies on the combined use of dexmedetomidine and levobupivacaine in I/R injury, it is anticipated that supporting these results with clinical studies may significantly contribute to clinical practice.

Indexed as

BupivacaineDexmedetomidineDisease Models, AnimalLevobupivacaineReperfusion InjuryAlanine TransaminaseAnesthetics, LocalAnimalsAntioxidantsAspartate AminotransferasesBiomarkersBlood GlucoseMaleMalondialdehydeOxidative StressRatsAlanine TransaminaseAnesthetics, LocalAntioxidantsAspartate AminotransferasesBiomarkersBlood GlucoseBupivacaineDexmedetomidineischemia-modified albuminLevobupivacaineMalondialdehydeSerum Albumin, HumanantioxidantdexmedetomidineIschemialevobupivacaineoxidative stress indexreperfusion

Identifiers

PMID39477431
PMCPMC11535938

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.