Evidence map›Paper›PMID 39477419›Full record

ArticleIn vivo (Athens, Greece)

Factors Associated With Mortality in Patients With Catheter-related Bloodstream Infection: A Multicenter Retrospective Study.

Akihiko Futamura, Takenao Koseki, Tsuyoshi Nakai, Nobuyuki Muroi, Michiaki Myotoku, Junichi Iida, Hiroki Maki, Akito Suzuki, Kazuhisa Mizutani, Hikaru Ogino and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Akihiko FutamuraDepartment of Pharmacy, Fujita Health University Nanakuri Memorial Hospital, Tsu, Japan; futamura@fujita-hu.ac.jp.
Takenao KosekiDepartment of Pharmacotherapeutics and Informatics, Fujita Health University School of Medicine, Toyoake, Japan.
Tsuyoshi NakaiDepartment of Pharmacotherapeutics and Informatics, Fujita Health University School of Medicine, Toyoake, Japan.
Nobuyuki MuroiDepartment of Pharmacy, Kobe City Medical Center General Hospital, Kobe, Japan.
Michiaki MyotokuFaculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan.
Junichi IidaHospitalization Support Center, Saiseikai Yokohama-shi Nanbu Hospital, Yokohama, Japan.
Hiroki MakiDepartment of Pharmacy, Kofu City Regional Medical Center, Kofu, Japan.
Akito SuzukiDepartment of Pharmaceutical Sciences, School of Pharmaceutical Sciences, Kyushu University of Medical Science, Nobeoka, Japan.
Kazuhisa MizutaniDepartment of Pharmacy, Toya Onsen Hospital, Toyako, Japan.
Hikaru OginoTokai Pharmacy, Tokai Pharmacy in front of Nakatsugawa Municipal Hospital, Nakatsugawa, Japan.
Yasuki TaniguchiDepartment of Pharmacy, Inabe General Hospital, Inabe, Japan.
Keiichiro HigashiDepartment of Pharmacy, Asanogawa General Hospital, Kanazawa, Japan.
Masanobu UsuiDepartment of Surgery and Palliative Medicine, Fujita Health University School of Medicine, Toyoake, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimCatheter-related bloodstream infections (CRBSI) are frequently life-threatening. Several factors have been reported to be related to CRBSI development; however, the factors associated with CRBSI mortality are unclear as they have rarely been studied. This study investigated the factors associated with mortality in patients with CRBSI, specifically focusing on nutritional factors. PATIENTS AND

methodsThis retrospective, multicenter study included in-patients with acute conditions and convalescent patients diagnosed with a CRBSI between January 2019 and December 2021 at 33 hospitals (23 general hospitals, two mixed-care hospitals, and eight convalescent hospitals). The primary outcome was death. Unadjusted and multivariable logistic regression analysis was performed to identify factors associated with mortality.

resultsA total of 453 patients with CRBSI were enrolled. The causes of death were analyzed for 382 (84.3%) who survived CRBSI and 71 (15.7%) who died. Multivariable analysis revealed that Candida detected in blood culture [adjusted odds ratio (aOR)=2.72, 95% confidence interval (CI)=1.15-6.41; p=0.025)], CRBSI onset within 30 days of catheter insertion (aOR=2.28, 95% CI=1.27-4.09; p=0.005), concurrent infection (aOR=2.07, 95% CI=1.19-3.60; p=0.009), low serum albumin level (aOR=1.64, 95% CI=1.02-2.63; p=0.044), and elevated C-reactive protein level (aOR=1.05, 95% CI=1.01-1.10; p=0.028) were risk factors for mortality, whereas the use of a peripherally inserted central catheter was associated with a reduced risk of CRBSI mortality (aOR=0.30, 95% CI=0.13-0.69; p=0.004).

conclusionEnhanced monitoring of factors, such as candida detected in blood culture, CRBSI onset within 30 days of catheter insertion, concurrent infection, low serum albumin level, elevated C-reactive protein (CRP) level and the use of a peripherally inserted central catheter (PICC), is crucial for mitigating CRBSI severity and risk of death.

Indexed as

Catheter-Related InfectionsAgedAged, 80 and overBacteremiaCatheterization, Central VenousFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsalbuminCandidaCatheter-related bloodstream infectionC-reactive proteinmortality

Identifiers

PMID39477419
PMCPMC11535952

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.