Evidence map›Paper›PMID 39477388›Full record

ArticleIn vivo (Athens, Greece)

Chemical Carcinogen (3-Methylcholanthrene)-induced Pleomorphic Rhabdomyosarcomas in Fanconi Anemia Fancd2-/-, Fancg-/- (C57BL/6), Fancd2-/- (129/Sv) Mice.

Renee Fisher, Michael W Epperly, Lora H Rigatti, Donna Shields, Joel S Greenberger, Anthony Green, Amitava Mukherjee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Renee FisherDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, U.S.A.
Michael W EpperlyDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, U.S.A.
Lora H RigattiDepartment of DLAR-Veterinary Services, University of Pittsburgh, Pittsburgh, PA, U.S.A.
Donna ShieldsDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, U.S.A.
Joel S GreenbergerDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, U.S.A. greenbergerjs@upmc.edu.
Anthony GreenDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, U.S.A.
Amitava MukherjeeDepartment of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA, U.S.A.

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
NCI NIH HHS P30 CA047904
6 · The paper itself

Abstract

BACKGROUND/

aimRadiation oncologists are reluctant to treat cancer in Fanconi Anemia (FA) patients due to their lack of homologous recombination repair of DNA strand breaks in normal tissues. To determine the therapeutic effects of irradiation and combination chemotherapy on cancer in syngeneic, radiosensitive FA mice, we derived transplantable cancers of the same genotype in three FA mouse strains. MATERIALS AND

methodsFancd2-/- mice on a C57BL/6 or Sv/129 background and Fancg-/- mice (C57BL/6 background) that received 3-methylcholanthrene (3-MCA), were monitored for the development of subcutaneous tumors.

resultsTumors were induced at the site of 3-MCA injection, and tumor cell lines were established and found to be transplantable. Explanted tumors were identified as pleomorphic/rhabdomyosarcomas using immunohistochemical biomarkers.

conclusionThese transplantable FA mouse tumor cell lines should be valuable for testing effects of new radiation therapy protocols including FLASH high dose rate radiation delivery, immunotherapies, and combined radiation and chemotherapy treatments for radiosensitive FA patients.

Indexed as

Fanconi AnemiaFanconi Anemia Complementation Group D2 ProteinFanconi Anemia Complementation Group G ProteinMethylcholanthreneMice, KnockoutRhabdomyosarcomaAnimalsCarcinogensCell Line, TumorDisease Models, AnimalHumansMiceMice, Inbred C57BLCarcinogensFancd2 protein, mouseFanconi Anemia Complementation Group D2 ProteinFanconi Anemia Complementation Group G ProteinMethylcholanthrene3-methylcholanthrenechemical carcinogenFanconi anemia mouse models

Identifiers

PMID39477388
PMCPMC11535948

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.