Evidence map›Paper›PMID 39477380›Full record

ArticleIn vivo (Athens, Greece)

FABP7: A Potential Diagnostic and Prognostic Biomarker for Clear Cell Renal Cell Carcinoma.

Chanita Panwoon, Wunchana Seubwai, Malinee Thanee, Sakkarn Sangkhamanon

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Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Chanita PanwoonDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Wunchana SeubwaiDepartment of Forensic Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Malinee ThaneeDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Sakkarn SangkhamanonDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; sakkarn@kku.ac.th.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimRenal cell carcinoma (RCC) is highly heterogeneous, with distinct patient management between clear cell RCC (ccRCC) and non-ccRCC groups. Previous bioinformatics and machine learning techniques identified fatty acid binding protein 7 (FABP7) as a potential ccRCC biomarker. However, FABP7 expression studies between ccRCC and non-ccRCC were incomplete. This study aimed to assess FABP7 as a biomarker for distinguishing between ccRCC and non-ccRCC tissue samples. PATIENTS AND

methodsFABP7 expression was evaluated via immunohistochemical staining in 58 RCC cases, including 43 ccRCC and 15 non-ccRCC cases. Staining results were interpreted using H-scores; scores above the cut-off were deemed positive. The correlation between FABP7 expression and clinicopathological RCC features was investigated.

resultsFABP7 positivity was 48.8% in ccRCC and only 13.3% in non-ccRCC cases, with weak positivity in non-ccRCC tissues. FABP7 expression significantly differed between ccRCC and non-ccRCC (p<0.05). This finding was confirmed in a TCGA dataset. However, FABP7 expression was not correlated with other RCC clinicopathological features in our dataset. TCGA results linked FABP7 expression to tumor stage and disease-free survival in patients with ccRCC.

conclusionThis study preliminarily evaluated FABP7 as a differential diagnostic biomarker in RCC subtyping, showing higher expression in ccRCC than non-ccRCC. FABP7 may serve as a potential diagnostic and prognostic biomarker for ccRCC.

Indexed as

Biomarkers, TumorCarcinoma, Renal CellFatty Acid-Binding Protein 7Kidney NeoplasmsAdultAgedAged, 80 and overFatty Acid-Binding ProteinsFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryMaleMiddle AgedNeoplasm StagingPrognosisBiomarkers, TumorFABP7 protein, humanFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsTumor Suppressor ProteinsClear cell renal cell carcinomadiagnostic markerFABP7immunohistochemistrynon-clear cell renal cell carcinoma

Identifiers

PMID39477380
PMCPMC11535899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.